1-Chloro-2-(2-nitro-phenylsulfanyl)-2,3,3a,4,5,9b-hexahydro-1H-cyclopenta[c]quinoline-4,6-dicarboxylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1-Chloro-2-(2-nitro-phenylsulfanyl)-2,3,3a,4,5,9b-hexahydro-1H-cyclopenta[c]quinoline-4,6-dicarboxylic acid
• 英文别名: 1-chloro-2-(2-nitrophenyl)sulfanyl-2,3,3a,4,5,9b-hexahydro-1H-cyclopenta[c]quinoline-4,6-dicarboxylic acid
• 化学式: C20H17ClN2O6S
• 分子量: 448.9
• InChiKey: JGVHSWXYIOECCL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  30
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  158
• 氢给体数：
  3
• 氢受体数：
  8

文献信息

• Methods and compositions for the inhibition of PIN1
  申请人：Beth Israel Deaconess Medical Center, Inc.

  公开号：US11129835B2

  公开（公告）日：2021-09-28

  The invention features compositions and methods for inhibiting the Pin1 protein, and the treatment of disorders characterized by elevated Pin1 levels.

  本发明的特点是抑制 Pin1 蛋白的组合物和方法，以及治疗以 Pin1 水平升高为特征的疾病。
• METHODS AND COMPOSITIONS FOR THE INHIBITION OF PIN1
  申请人：Beth Israel Deaconess Medical Center, Inc.

  公开号：US20150133442A1

  公开（公告）日：2015-05-14

  The invention features compositions and methods for inhibiting the Pin1 protein, and the treatment of disorders characterized by elevated Pin1 levels.
• ARSENIC TRIOXIDE FOR TREATMENT OF PIN1-ASSOCIATED DISORDERS
  申请人：Beth Israel Deaconess Medical Center, Inc.

  公开号：US20180153934A1

  公开（公告）日：2018-06-07

  The present invention relates to the treatment of Pin1-associated disorders (e.g., disorders characterized by elevated Pin1 activity) with arsenic trioxide, optionally in combination with a retinoic acid compound. Pin1-associated disorders may include, for example, proliferative disorders (e.g., cancers), inflammatory conditions, and autoimmune disorders associated with aberrant levels of Pin1 activity.
• US9730941B2
  申请人：——

  公开号：US9730941B2

  公开（公告）日：2017-08-15