1-chloro-4-(2-nitrophenyl)-2-(2-nitrophenyl)sulfanyl-2,3,3a,4,5,9b-hexahydro-1H-cyclopenta[c]quinoline-6-carboxylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1-chloro-4-(2-nitrophenyl)-2-(2-nitrophenyl)sulfanyl-2,3,3a,4,5,9b-hexahydro-1H-cyclopenta[c]quinoline-6-carboxylic acid
• 化学式: C25H20ClN3O6S
• 分子量: 526.0
• InChiKey: OTHQNINSJWIIPA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  36
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  166
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• FABP4 as a therapeutic target in skin diseases
  申请人：TICURE LTD.

  公开号：US11229624B2

  公开（公告）日：2022-01-25

  Provided are methods of regulating proliferation and/or differentiation of keratinocytes and immune cells, more specifically to methods of treating pathologies characterized by hyperproliferative keratinocytes or inflammatory skin diseases by administration of FABP4-inhibitor.

  本发明提供了调节角质细胞和免疫细胞增殖和/或分化的方法，更具体地说，提供了通过服用 FABP4 抑制剂治疗以角质细胞过度增殖或炎症性皮肤病为特征的病症的方法。
• FABP4 AS A THERAPEUTIC TARGET IN SKIN DISEASES
  申请人：TICURE LTD.

  公开号：US20200138779A1

  公开（公告）日：2020-05-07

  Provided are methods of regulating proliferation and/or differentiation of keratinocytes and immune cells, more specifically to methods of treating pathologies characterized by hyperproliferative keratinocytes or inflammatory skin diseases by administration of FABP4-inhibitor.