4-(2-nitrophenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4-(2-nitrophenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide
• 化学式: C18H17N3O4S
• 分子量: 371.4
• InChiKey: FRZVWENMAQXFAK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  26
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  126
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• Positive modulators of nicotinic acetylcholine receptors
  申请人：Becker Christopher

  公开号：US20070179172A1

  公开（公告）日：2007-08-02

  Compounds of Formula I or Formula II wherein R 1 , X and Ar are as described in the specification, pharmaceutically-acceptable salts thereof, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, especially for treatment of conditions associated with reductions in nicotinic transmission.

  公式I或公式II的化合物，其中R1、X和Ar如规范描述，其药学上可接受的盐，制备它们的过程，包含它们的制药组合物以及它们在治疗中的使用，特别是用于治疗与尼古丁传递减少有关的病症。
• POSITIVE MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS
  申请人：AstraZeneca AB

  公开号：EP1631288A1

  公开（公告）日：2006-03-08
• LIGANDS FOR ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTORS AND METHODS OF TREATING NEUROLOGICAL AND INFLAMMATORY CONDITIONS
  申请人：Northeastern University

  公开号：EP3180086A1

  公开（公告）日：2017-06-21
• Ligands for Alpha-7 Nicotinic Acetylcholine Receptors and Methods of Treating Neurological and Inflammatory Conditions
  申请人：Northeastern University

  公开号：US20170217984A1

  公开（公告）日：2017-08-03

  Compounds are provided which bind to an allosteric site on the mammalian alpha-7 nicotinic acetylcholine receptor (alpha-7 nAChR) and act as positive allosteric modulators with or without allosteric agonist activity. The compounds are useful in diagnosing, preventing, or treating a variety of disorders involving cognition, learning, memory, neurodegeneration, drug addiction, inflammation, chronic pain, and neuropathic pain. The compounds also can be used to enhance memory and learning in normal individuals.
• [EN] POSITIVE MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS<br/>[FR] MODULATEURS POSITIFS DES RECEPTEURS DE L'ACETYLCHOLINE NICOTINIQUE
  申请人：ASTRAZENECA AB

  公开号：WO2004098600A1

  公开（公告）日：2004-11-18

  Compounds of Formula (I) or Formula (II) wherein R1, X and Ar are as described in the specification, pharmaceutically-acceptable salts thereof, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, especially for treatment of conditions associated with reductions in nicotinic transmission.