(2Z)-3-ethyl-2-[(1-ethylquinolin-1-ium-2-yl)methylidene]-6-methyl-1,3-benzothiazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: (2Z)-3-ethyl-2-[(1-ethylquinolin-1-ium-2-yl)methylidene]-6-methyl-1,3-benzothiazole
• 化学式: C22H23N2S+
• mdl: MFCD03444789
• 分子量: 347.5
• InChiKey: RBRVMADVSBTEGC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  32.4
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• ANTI-NEURODEGENERATIVE DISEASE AGENT
  申请人：Hayashibara Co., Ltd.

  公开号：US20220031690A1

  公开（公告）日：2022-02-03

  The present invention addresses the problem of providing an orally-administrable anti-neurodegenerative disease agent having an action of accelerating neurocyte growth and an action of promoting neurite-outgrowth, and having excellent transfer properties to central nervous tissues. The problem is solved by providing an anti-neurodegenerative disease agent containing a compound represented by General formula 4 as an active ingredient, and having an action of accelerating neurocyte growth, an action of promoting neurite-outgrowth, and an action of scavenging reactive oxygen species. In General formula 4, R 10 and R 11 represent the same or different alkyl group having 2-8 carbon atoms, and the alkyl group may be either a straight chain or a branched chain. n represents an integer of 0 or 1, and X 4 − represents a suitable counter anion that is pharmaceutically acceptable.