3-phenyl-N-[2,2,2-trichloro-1-[(2-sulfanylphenyl)carbamothioylamino]ethyl]prop-2-enamide

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: 3-phenyl-N-[2,2,2-trichloro-1-[(2-sulfanylphenyl)carbamothioylamino]ethyl]prop-2-enamide
• 化学式: C₁₈H₁₆Cl₃N₃OS₂
• 分子量: 460.8
• InChiKey: IAUFTWQYTHTPFY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  86.2
• 氢给体数：
  4
• 氢受体数：
  3

文献信息

• Nitrogen-containing compounds and their use as glycine transport inhibitors
  申请人：Gliatech, Inc.

  公开号：US20020082283A1

  公开（公告）日：2002-06-27

  A method for the inhibition of high affinity glycine transporters, compounds that inhibit these transporters; pharmaceutically active compositions comprising such compounds; and the use of such compounds either as above, or in formulations for the control or prevention of disease states in which glycine is involved are disclosed.

  本发明公开了一种抑制高亲和力甘氨酸转运体的方法，抑制这些转运体的化合物；包含这种化合物的药用活性组合物；以及将这种化合物用于上述用途，或用于控制或预防涉及甘氨酸的疾病状态的制剂。
• NITROGEN-CONTAINING COMPOUNDS AND THEIR USE AS GLYCINE TRANSPORT INHIBITORS
  申请人：GLIATECH, INC.

  公开号：EP1324986A1

  公开（公告）日：2003-07-09
• US6946474B2
  申请人：——

  公开号：US6946474B2

  公开（公告）日：2005-09-20
• [EN] NITROGEN-CONTAINING COMPOUNDS AND THEIR USE AS GLYCINE TRANSPORT INHIBITORS<br/>[FR] COMPOSES AZOTES ET LEUR UTILISATION COMME INHIBITEURS DE TRANSPORT DE LA GLYCINE
  申请人：GLIATECH INC

  公开号：WO2002022581A1

  公开（公告）日：2002-03-21

  A method for the inhibition of high affinity glycine transporters, compounds that inhibit these transporters; pharmaceutically active compositions comprising such compounds; and the use of such compounds either as above, or in formulations for the control or prevention of disease states in which glycine is involved are disclosed.