1-(3-Diethylamino-propyl)-3-(3-dimethylamino-propyl)-1-(6-oxo-5,6-dihydro-[1,3]dioxolo[4,5-g]quinolin-7-ylmethyl)-thiourea

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1-(3-Diethylamino-propyl)-3-(3-dimethylamino-propyl)-1-(6-oxo-5,6-dihydro-[1,3]dioxolo[4,5-g]quinolin-7-ylmethyl)-thiourea
• 英文别名: 1-[3-(diethylamino)propyl]-3-[3-(dimethylamino)propyl]-1-[(6-oxo-5H-[1,3]dioxolo[4,5-g]quinolin-7-yl)methyl]thiourea
• 化学式: C₂₄H₃₇N₅O₃S
• 分子量: 475.6
• InChiKey: AJEHNNVDEZAAHB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  33
• 可旋转键数：
  12
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  101
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• [EN] Inhibitors of RAD52 Recombination Protein and Methods Using Same<br/>[FR] INHIBITEURS DE LA PROTÉINE DE RECOMBINAISON RAD52 ET PROCÉDÉS D'UTILISATION DE CEUX-CI
  申请人：UNIV DREXEL

  公开号：WO2016196955A1

  公开（公告）日：2016-12-08

  The present invention includes novel RAD52 inhibitors for preventing or treating cancers in a subject in need thereof. The present invention further includes a method of preventing or treating cancers in a subject in need thereof, the method comprising administering to the subject an effective amount of a compound of the invention. In certain embodiments, the subject is further administered at least one additional therapeutic agent.

  本发明包括用于预防或治疗患有癌症的受试者的新型RAD52抑制剂。本发明还包括一种预防或治疗患有癌症的受试者的方法，该方法包括向受试者投与本发明化合物的有效量。在某些实施方式中，受试者还会投与至少一种其他治疗药物。
• Inhibitors of RAD52 recombination protein and methods using same
  申请人：Mazin Alexander V.

  公开号：US10442817B2

  公开（公告）日：2019-10-15

  The present invention includes novel RAD52 inhibitors for preventing or treating cancers in a subject in need thereof. The present invention further includes a method of preventing or treating cancers in a subject in need thereof, the method comprising administering to the subject an effective amount of a compound of the invention. In certain embodiments, the subject is further administered at least one additional therapeutic agent.

  本发明包括新型 RAD52 抑制剂，用于预防或治疗有需要的受试者的癌症。本发明还包括一种预防或治疗有需要的受试者癌症的方法，该方法包括向受试者施用有效量的本发明化合物。在某些实施方案中，受试者进一步施用至少一种额外的治疗剂。
• Inhibitors of RAD52 Recombination Protein and Methods Using Same
  申请人：MAZIN Alexander V.

  公开号：US20180134727A1

  公开（公告）日：2018-05-17

  The present invention includes novel RAD52 inhibitors for preventing or treating cancers in a subject in need thereof. The present invention further includes a method of preventing or treating cancers in a subject in need thereof, the method comprising administering to the subject an effective amount of a compound of the invention. In certain embodiments, the subject is further administered at least one additional therapeutic agent.