N-cyclohexyl-2-[[2-[2-[(5-methyl-1,2-oxazol-3-yl)amino]-2-oxoethyl]sulfanylacetyl]-quinolin-3-ylamino]-2-thiophen-2-ylacetamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N-cyclohexyl-2-[[2-[2-[(5-methyl-1,2-oxazol-3-yl)amino]-2-oxoethyl]sulfanylacetyl]-quinolin-3-ylamino]-2-thiophen-2-ylacetamide
• 化学式: C₂₉H₃₁N₅O₄S₂
• 分子量: 577.7
• InChiKey: BHCTXPZDPMLBKX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  40
• 可旋转键数：
  10
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.34
• 拓扑面积：
  171
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• Compositions useful in treating brain-related diseases or disorders and methods using same
  申请人：DREXEL UNIVERSITY

  公开号：US10287290B2

  公开（公告）日：2019-05-14

  The present invention provides compounds useful for treating or preventing a brain-related disease or disorder. The present invention further provides a method of treating or preventing a brain-related disease or disorder in a patient, comprising administering to the patient a pharmaceutical composition comprising at least one compound of the invention. The present invention further provides a method of modulating the activity of a monoamine transporter.

  本发明提供了用于治疗或预防脑相关疾病或紊乱的化合物。本发明进一步提供了一种治疗或预防患者脑相关疾病或紊乱的方法，包括向患者施用包含至少一种本发明化合物的药物组合物。本发明进一步提供了一种调节单胺转运体活性的方法。
• NOVEL COMPOSITIONS USEFUL IN TREATING BRAIN-RELATED DISEASES OR DISORDERS AND METHODS USING SAME
  申请人：DREXEL UNIVERSITY

  公开号：US20160074408A1

  公开（公告）日：2016-03-17

  The present invention provides compounds useful for treating or preventing a brain-related disease or disorder. The present invention further provides a method of treating or preventing a brain-related disease or disorder in a patient, the method comprising administering to the patient a pharmaceutical composition comprising at least one compound of the invention. The present invention further provides a method of modulating the activity of a monoamine transporter.
• US9616065B2
  申请人：——

  公开号：US9616065B2

  公开（公告）日：2017-04-11
• [EN] NOVEL COMPOSITIONS USEFUL IN TREATING BRAIN-RELATED DISEASES OR DISORDERS AND METHODS USING SAME<br/>[FR] NOUVELLES COMPOSITIONS UTILISÉES POUR LE TRAITEMENT DE MALADIES OU D'AFFECTIONS LIÉES AU CERVEAU, ET MÉTHODES UTILISANT CES COMPOSITIONS
  申请人：PHILADELPHIA HEALTH & EDUCATIO

  公开号：WO2014172453A2

  公开（公告）日：2014-10-23

  The present invention provides compounds useful for treating or preventing a brain-related disease or disorder. The present invention further provides a method of treating or preventing a brain-related disease or disorder in a patient, comprising administering to the patient a pharmaceutical composition comprising at least one compound of the invention. The present invention further provides a method of modulating the activity of a monoamine transporter.