1,3,4,5-tetramethyl-imidazolium-2-carboxylate | 1188360-01-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1,3,4,5-tetramethyl-imidazolium-2-carboxylate
• 英文别名: 1,3,4,5-Tetramethylimidazol-1-ium-2-carboxylate
• CAS: 1188360-01-1
• 化学式: C₈H₁₂N₂O₂
• 分子量: 168.195
• InChiKey: YKWLBQHKOZSJBQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  48.9
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  二氧化碳 、 1,3,4,5-tetramethyl-2,3-dihydro-1H-imidazol-2-thione 在 氢化钾 作用下， 以 四氢呋喃 为溶剂， 反应 2.0h， 以78%的产率得到1,3,4,5-tetramethyl-imidazolium-2-carboxylate
  参考文献：
  名称：

  A Systematic Investigation of Factors Influencing the Decarboxylation of Imidazolium Carboxylates

  摘要：

  A series of 1,3-disubstituted-2-imidazolium carboxylates, an adduct of CO2 and N-heterocyclic carbenes, were synthesized and characterized using single crystal X-ray, thermogravimetric, IR, and NMR analysis. The TGA analysis of the NHC-CO2's shows that as steric bulk on the N-substituent increases, the ability of the NHC-CO2 to decarboxylate increases. The comparison of NHC-CO2's with and without methyls at the 4,5-position indicate that extra electron density in the imidazolium ring enhances the stability of an NHC-CO2 thereby making it less prone to decarboxylation. Single crystal X-ray analysis shows that the torsional angle of the carboxylate group and the C-CO2 bond length with respect to the imidazolium ring is dependent on the steric bulk of the N-substituent. Rotamers in the unit cell of a single crystal of I'BuPrCO2 (2f) indicate that the C-CO2 bond length increases as the N-substituents rotate toward the carboxylate moiety, which suggests that rotation of the N-substituents through the plane of the C-CO2 bond may be involved in the bond breaking event to release CO2.

  DOI：

  10.1021/jo901791k

文献信息

• PRODUCTION METHOD FOR AMIDATE COMPOUND
  申请人：Koei Chemical Company, Limited

  公开号：EP3604287A1

  公开（公告）日：2020-02-05

  A method for producing an amidate compound represented by Formula (3), comprising reacting a urethane compound represented by Formula (1) with a carboxylate compound represented by Formula (2): (in the formulas, A, n, R1, R2, R3, R4, R5, R6, X, and a are as described in the Description).

  一种生产式（3）代表的酰胺化合物的方法，包括使式（1）代表的聚氨酯化合物与式（2）代表的羧酸化合物反应： (式中，A、n、R1、R2、R3、R4、R5、R6、X 和 a 如说明书所述）。
• CATALYST FOR DISSOCIATION OF BLOCKING AGENT FOR BLOCKED ISOCYANATES, AND THERMOSETTING COMPOSITION CONTAINING SAID CATALYST FOR DISSOCIATION OF BLOCKING AGENT
  申请人：Koei Chemical Company, Limited

  公开号：EP3689931A1

  公开（公告）日：2020-08-05

  A blocking agent dissociation catalyst for blocked isocyanates comprising a nitrogen-containing compound represented by Formula (1a): wherein D is represented by Formula (2): wherein R1, R2, R3, R4, and a are as described in the specification.

  一种用于封端异氰酸酯的封端剂解离催化剂，由式（1a）代表的含氮化合物组成： 其中 D 由式（2）表示： 其中 R1、R2、R3、R4 和 a 如说明书所述。
• Production method for amidate compound
  申请人：KOEI CHEMICAL COMPANY, LIMITED

  公开号：US10913724B2

  公开（公告）日：2021-02-09

  A method for producing an amidate compound represented by Formula (3), comprising reacting a urethane compound represented by Formula (1) with a carboxylate compound represented by Formula (2): (in the formulas, A, n, R1, R2, R3, R4, R5, R6, X, and a are as described in the Description).

  一种生产式（3）代表的酰胺化合物的方法，包括使式（1）代表的聚氨酯化合物与式（2）代表的羧酸化合物反应： (式中，A、n、R1、R2、R3、R4、R5、R6、X 和 a 如说明书所述）。
• US9863048B2
  申请人：——

  公开号：US9863048B2

  公开（公告）日：2018-01-09
• A Systematic Investigation of Factors Influencing the Decarboxylation of Imidazolium Carboxylates
  作者：Bret R. Van Ausdall、Jeremy L. Glass、Kelly M. Wiggins、Atta M. Aarif、Janis Louie

  DOI：10.1021/jo901791k

  日期：2009.10.16

  A series of 1,3-disubstituted-2-imidazolium carboxylates, an adduct of CO2 and N-heterocyclic carbenes, were synthesized and characterized using single crystal X-ray, thermogravimetric, IR, and NMR analysis. The TGA analysis of the NHC-CO2's shows that as steric bulk on the N-substituent increases, the ability of the NHC-CO2 to decarboxylate increases. The comparison of NHC-CO2's with and without methyls at the 4,5-position indicate that extra electron density in the imidazolium ring enhances the stability of an NHC-CO2 thereby making it less prone to decarboxylation. Single crystal X-ray analysis shows that the torsional angle of the carboxylate group and the C-CO2 bond length with respect to the imidazolium ring is dependent on the steric bulk of the N-substituent. Rotamers in the unit cell of a single crystal of I'BuPrCO2 (2f) indicate that the C-CO2 bond length increases as the N-substituents rotate toward the carboxylate moiety, which suggests that rotation of the N-substituents through the plane of the C-CO2 bond may be involved in the bond breaking event to release CO2.