N-cyclopentyl-8-methoxy-4-oxo-1H-quinoline-3-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N-cyclopentyl-8-methoxy-4-oxo-1H-quinoline-3-carboxamide
• 化学式: C₁₆H₁₈N₂O₃
• 分子量: 286.33
• InChiKey: LOAFNHZXLMSMQJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  67.4
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• 4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXAMIDE AS SELECTIVE LIGAND FOR CANNABINOID RECEPTOR 2 FOR DIAGNOSIS AND THERAPY
  申请人：ETH Zürich

  公开号：EP3166930A1

  公开（公告）日：2017-05-17
• [EN] 4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXAMIDE AS SELECTIVE LIGAND FOR CANNABINOID RECEPTOR 2 FOR DIAGNOSIS AND THERAPY<br/>[FR] 4-OXO-1,4-DIHYDROQUINOLÉINE-3-CARBOXAMIDE UTILISÉ COMME LIGAND SÉLECTIF POUR LE RÉCEPTEUR DE CANNABINOÏDES 2 POUR LE DIAGNOSTIC ET LA THERAPIE
  申请人：ETH ZUERICH

  公开号：WO2016005419A1

  公开（公告）日：2016-01-14

  The present invention is directed to new compounds of formula (I) selectively binding the cannabinoid 2 receptor. In addition, the invention relates to the use of said compounds for determining cannabinoid receptor 2 (CB2)-selective receptor localization and density, preferably in the central nervous system (CNS), the peripheral nervous system (PNS), heart, liver, gastrointestinal tract, spleen, pancreas, kidney, testis, ovary and/or the prostate. Moreover, the invention pertains to the use of said compounds in the diagnosis, prophylaxis and/or therapy of CB2 receptor-related diseases.