(4-hydroxy-6,8-dimethoxyquinolin-3-yl)(4-methylpiperazin-1-yl)methanone

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: (4-hydroxy-6,8-dimethoxyquinolin-3-yl)(4-methylpiperazin-1-yl)methanone
• 英文别名: 6,8-dimethoxy-3-(4-methylpiperazine-1-carbonyl)-1H-quinolin-4-one
• 化学式: C₁₇H₂₁N₃O₄
• 分子量: 331.371
• InChiKey: COMJBYRLBLXCGS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  71.1
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• 5HT1F receptor agonists and mitochondrial biogenesis
  申请人：MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

  公开号：US11014892B2

  公开（公告）日：2021-05-25

  Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, promote mitochondrial biogenesis and are useful for the treatment of, for example, acute kidney injury and chronic kidney disease.

  本文提供了式(I)：的化合物及其药学上可接受的盐类，其中取代基与说明书中公开的相同。这些化合物以及含有它们的药物组合物能促进线粒体的生物生成，可用于治疗急性肾损伤和慢性肾病等。
• 5HT1F RECEPTOR AGONISTS AND MITOCHONDRIAL BIOGENESIS
  申请人：MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

  公开号：US20200055827A1

  公开（公告）日：2020-02-20

  Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, promote mitochondrial biogenesis and are useful for the treatment of, for example, acute kidney injury and chronic kidney disease.