6-bromo-4-(3,4,5-trimethoxyphenyl)-3,4-dihydrobenzo[h]quinolin-2(1H)-one | 297157-87-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 6-bromo-4-(3,4,5-trimethoxyphenyl)-3,4-dihydrobenzo[h]quinolin-2(1H)-one
• 英文别名: 6-bromo-4-(3,4,5-trimethoxyphenyl)-3,4-dihydro-1H-benzo[h]quinolin-2-one
• CAS: 297157-87-0
• 化学式: C₂₂H₂₀BrNO₄
• 分子量: 442.3
• InChiKey: KPOXOTVERMGJQS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  56.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• SMALL MOLECULE INHIBITORS OF THE ALPHA4-PAXILLIN INTERACTION
  申请人：Ginsberg Mark

  公开号：US20120245194A1

  公开（公告）日：2012-09-27

  The present invention is directed to novel compounds that are able to inhibit the interaction of paxillin or its paralogues, including leupaxin or Hic-5, with alpha.4 integrin or its binding partners that regulate signaling events downstream of the paxillin-alpha.4 interaction. The present invention further relates to methods for therapeutic use of such compounds and pharmaceutical compositions of such compounds for the treatment of a disease or condition.
• US8987294B2
  申请人：——

  公开号：US8987294B2

  公开（公告）日：2015-03-24
• [EN] SMALL MOLECULE INHIBITORS OF THE ALPHA4-PAXILLIN INTERACTION<br/>[FR] INHIBITEURS À PETITES MOLÉCULES DE L'INTERACTION ALPHA4-PAXILLINE
  申请人：UNIV CALIFORNIA

  公开号：WO2011034896A2

  公开（公告）日：2011-03-24

  The present invention is directed to novel compounds that are able to inhibit the interaction of paxillin or its paralogues, including leupaxin or Hic-5f with alpha.4 integrin or its binding partners that regulate signaling events downstream of the paxillin~,alpha.4 interaction, The present invention further relates to methods for therapeutic use of such compounds and pharmaceutical compositions of such compounds for the treatment of a disease or condition.