2-[[(R)-(8-hydroxyquinolin-7-yl)-phenylmethyl]amino]benzoic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-[[(R)-(8-hydroxyquinolin-7-yl)-phenylmethyl]amino]benzoic acid
• 化学式: C₂₃H₁₈N₂O₃
• 分子量: 370.4
• InChiKey: NISNWVZYKYOKOX-HXUWFJFHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  82.4
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• MYCOBACTERIAL SULFATION PATHWAY PROTEINS AND METHODS OF USE THEREOF
  申请人：BERTOZZI Carolyn R.

  公开号：US20080175869A1

  公开（公告）日：2008-07-24

  Novel mycobacterial sulfation pathway proteins and polypeptides related thereto, as well as nucleic acid compositions encoding the same, are provided. The subject polypeptide and nucleic acid compositions find use in a variety of applications, including research, diagnostic, and therapeutic agent screening applications. Also provided are methods of inhibiting growth and/or virulence of a pathogenic mycobacterium, and methods of treating disease conditions associated with a pathogenic mycobacterium, particularly by administering an inhibitor of a mycobacterial sulfation pathway protein. The present invention further provides genetically modified mycobacteria having a defect in a sulfation pathway enzyme gene; and immunogenic compositions that include such genetically modified mycobacteria.
• US7344703B2
  申请人：——

  公开号：US7344703B2

  公开（公告）日：2008-03-18