1-Methyl-3-oxo-8a-ethoxycarbonyl-Δ⁴-octalin | 17299-53-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-Methyl-3-oxo-8a-ethoxycarbonyl-Δ⁴-octalin
• 英文别名: optically inactive 5-methyl-7-oxo-1,3,4,5,6,7-hexahydro-2H-naphthalene-4a-carboxylic acid ethyl ester；Opt. inakt. 5-Methyl-7-oxo-1,3,4,5,6,7-hexahydro-2H-naphthalin-4a-carbonsaeure-aethylester；Ethyl 5-methyl-7-oxo-1,2,3,4,5,6-hexahydronaphthalene-4a-carboxylate；ethyl 5-methyl-7-oxo-1,2,3,4,5,6-hexahydronaphthalene-4a-carboxylate
• CAS: 17299-53-5
• 化学式: C₁₄H₂₀O₃
• 分子量: 236.311
• InChiKey: VZSDXCRQKRIPBL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-Methyl-3-oxo-8a-ethoxycarbonyl-Δ⁴-octalin 在 氢氧化钾 作用下， 生成 1-Methyl-3-oxo-Δ⁴-octalin
  参考文献：
  名称：

  Alkyl-substitution effects in the photochemistry of 2-cyclohexenenones

  摘要：

  DOI：

  10.1021/jo01275a013
• 作为产物：
  描述：

  4-羟基戊烷-2-酮 在 potassium ethoxide 、 碘 作用下， 生成 1-Methyl-3-oxo-8a-ethoxycarbonyl-Δ⁴-octalin
  参考文献：
  名称：

  A bacterial sensor of plant cell contact controls the transcriptional induction of Ralstonia solanacearum pathogenicity genes

  摘要：

  The hrp genes of the plant pathogen Ralstonia solanacearum are key pathogenicity determinants; they encode a type III protein secretion machinery involved in the secretion of mediators of the bacterium-plant interaction. These hrp genes are under the genetic control of the hrpB regulatory gene, expression of which is induced when bacteria are co-cultivated with plant cell suspensions. In this study, we used hrp-gfp transcriptional fusions to demonstrate that the expression of the hrpB and type LII secretion genes is specifically induced in response to the bacterium-plant cell contact. This contact-dependent induction of hrpB gene expression requires the outer membrane protein PrhA, but not a functional type III secretion apparatus. Genetic evidence indicates that PrhA constitutes the first example of a bacterial receptor for a non-diffusible signal present in the plant cell wall and which triggers the transcriptional activation of bacterial virulence genes.

  DOI：

  10.1093/emboj/19.10.2304

文献信息

• Solid-Supported Robinson Annulation under Microwave Irradiation.
  作者：Kazuhiko Takatori、Masayasu Nakayama、Naoko Futaishi、Saori Yamada、Shinobu Hirayama、Masahiro Kajiwara

  DOI：10.1248/cpb.51.455

  日期：——

  Robinson annulation on alumina occurred efficiently on heating with microwave irradiation.

  在微波辐照加热下，Robinson环化反应在氧化铝上有效地发生了。