dichloro-acetic acid-[1-chloromethyl-2-(4-chloro-phenyl)-2-oxo-ethylamide] | 85409-44-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: dichloro-acetic acid-[1-chloromethyl-2-(4-chloro-phenyl)-2-oxo-ethylamide]
• 英文别名: (+/-)-3-Chlor-1-(4-chlor-phenyl)-2-(2,2-dichlor-acetylamino)-propan-1-on；Dichlor-essigsaeure-[1-chlormethyl-2-(4-chlor-phenyl)-2-oxo-aethylamid]；2,2-dichloro-N-[1-(chloromethyl)-2-(4-chlorophenyl)-2-oxoethyl]acetamide；Cloponone；2,2-dichloro-N-[3-chloro-1-(4-chlorophenyl)-1-oxopropan-2-yl]acetamide
• CAS: 85409-44-5
• 化学式: C₁₁H₉Cl₄NO₂
• 分子量: 329.01
• InChiKey: MLVKMSCFQIQULM-UHFFFAOYSA-N

物化性质

• 熔点：
  119 °C
• 沸点：
  508.7±50.0 °C(Predicted)
• 密度：
  1.473±0.06 g/cm3(Predicted)
• 保留指数：
  2011

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  46.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  dichloro-acetic acid-[2-(4-chloro-phenyl)-1-hydroxymethyl-2-oxo-ethylamide] 在 氯化亚砜 作用下， 生成 dichloro-acetic acid-[1-chloromethyl-2-(4-chloro-phenyl)-2-oxo-ethylamide]
  参考文献：
  名称：

  Logemann et al., Farmaco, Edizione Scientifica, 1958, vol. 13, p. 129,136

  摘要：

  DOI：

文献信息

• Diagnostic/therapeutic agents
  申请人：Klaveness Jo

  公开号：US20050002865A1

  公开（公告）日：2005-01-06

  Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, comprising a suspension in an aqueous carrier liquid of a reporter comprising gas-containing or gas-generating material, said agent being capable of forming at least two types of binding pairs with a target.

  可定位的诊断和/或治疗活性剂，例如超声对比剂，包括悬浮在水载体液中的报告物，该报告物包含含气体或生成气体的材料，该剂能够与目标形成至少两种结合对。
• Controlled absorption water-soluble pharmaceutically active organic compound formulation for once-daily administration
  申请人：Counts David F.

  公开号：US10463611B2

  公开（公告）日：2019-11-05

  The present disclosure provides a once-daily water-soluble pharmaceutically active formulation for oral administration. In certain embodiments, the composition comprises a water-soluble pharmaceutically active organic compound incorporated into a small particulate, each particulate having a core of the water-soluble pharmaceutically active organic compound or an acceptable salt thereof in reversible association with a pharmaceutically acceptable drug-binding polymer. The core of the composition being surrounded by an insoluble water permeable membrane that is capable of delaying the dissolution of the pharmaceutically active compound therewithin and providing for extended release of the pharmaceutically active compound. In some embodiments, the formulation of the invention are designed to extend release of the pharmaceutically active organic compound for about 3 hours to about 8 hours, thereby enabling preparation of an extended release formulation for any pharmaceutically active compound with a half-life of from about 16 hours to about 21 hours.

  本公开提供了一种用于口服的每日一次水溶性药用活性制剂。在某些实施方案中，该组合物包括掺入小颗粒中的水溶性药用活性有机化合物，每个颗粒都有一个水溶性药用活性有机化合物或其可接受盐的核心，该核心与药学上可接受的药物结合聚合物可逆结合。组合物的核心由不溶性透水膜包围，该膜能够延迟其中的药用活性化合物的溶解，并延长药用活性化合物的释放时间。在某些实施方案中，本发明的制剂可将药用活性有机化合物的释放时间延长约 3 小时至约 8 小时，从而能够制备半衰期为约 16 小时至约 21 小时的任何药用活性化合物的缓释制剂。
• Wound closure systems for reducing surgical site infections comprising incision drapes filled with releasable antimicrobial agents
  申请人：Ethicon, Inc.

  公开号：US11452641B2

  公开（公告）日：2022-09-27

  A surgical incision drape, comprises a flexible substantially flat areal substrate having an upper side and an opposing tissue-facing side, having a longitudinal axis and a pressure sensitive adhesive disposed on the tissue-facing side; at least one hollow microtubular compartment containing a flowable medical agent, said hollow microtubular compartment positioned to intersect the longitudinal axis and embedded into the substrate or positioned on the substrate.

  一种手术切口敷料，包括一个柔性大体平坦的基底，基底有一个上侧和一个相对的面向组织的侧，基底有一个纵轴，面向组织的侧上有一个压敏粘合剂；至少一个中空微管隔室，内装可流动的医用制剂，所述中空微管隔室的位置与纵轴相交，并嵌入基底或设置在基底上。
• LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY
  申请人：Scidose, Llc

  公开号：EP1954244A1

  公开（公告）日：2008-08-13
• CONTROLLED ABSORPTION WATER-SOLUBLE PHARMACEUTICALLY ACTIVE ORGANIC COMPOUND FORMULATION FOR ONCE-DAILY ADMINISTRATION
  申请人：STI Pharma, LLC

  公开号：EP2717860A1

  公开（公告）日：2014-04-16