(3aR,5S,6aS)-5-(2,2-dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyl-3a,5,6,6a-tetrahydrofuro[2,3-d][1,3]dioxol-6-ol

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (3aR,5S,6aS)-5-(2,2-dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyl-3a,5,6,6a-tetrahydrofuro[2,3-d][1,3]dioxol-6-ol
• 化学式: C₁₂H₂₀O₆
• 分子量: 260.28
• InChiKey: KEJGAYKWRDILTF-PGQYJIMISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  66.4
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• METHOD FOR PRODUCING 18F-LABELED COMPOUND AND HIGH MOLECULAR COMPOUND TO BE USED IN THE METHOD
  申请人：Takahashi Takashi

  公开号：US20120329968A1

  公开（公告）日：2012-12-27

  The present invention aims at solving the problems of conventional methods for producing an 18 F-labeled compound, that is, the problem of purification of a compound in a liquid phase synthesis method and the problem of an insufficient yield due to the reduction of reactivity in a solid phase synthesis method. There is provided a method for producing an 18 F-labeled compound including: allowing a high molecular compound containing a residue of a precursor compound to be labeled and a residue of a phase transfer catalyst in the molecule thereof to react with 18 F − ; and removing the 18 F-labeled compound from the high molecular compound.

  本发明的目的在于解决传统的18F-标记化合物生产方法的问题，即液相合成方法中化合物的纯化问题和固相合成方法中由于反应性降低导致产率不足的问题。提供了一种生产18F-标记化合物的方法，包括：使含有待标记前体化合物的残基和分子中的相转移催化剂残基的高分子化合物与18F-反应；并从高分子化合物中去除18F-标记化合物。
• O-acetyl-ADP-ribose non-hydrolyzable analogs
  申请人：Denu John M.

  公开号：US20070225246A1

  公开（公告）日：2007-09-27

  Compounds, compositions and methods for modulating cell death in target cells, particularly cancer cells are provided. The compounds are analogs of O-acetyl-ADP-ribose (OAADPr).

  提供了用于调节靶细胞死亡的化合物、组合物和方法，特别是癌细胞。这些化合物是O-乙酰-ADP-核糖（OAADPr）的类似物。
• Oligonucleotides comprising a ligand tethered to a modified or non-natural nucleobase
  申请人：Manoharan Muthiah

  公开号：US20070054279A1

  公开（公告）日：2007-03-08

  One aspect of the present invention relates to a double-stranded oligonucleotide comprising at least one ligand tethered to an altered or non-natural nucleobase. In certain embodiments, the non-natural nucleobase is difluorotolyl, nitropyrrolyl, or nitroimidazolyl. In certain embodiments, the ligand is a steroid or aromatic compound. In certain embodiments, only one of the two oligonucleotide strands comprising the double-stranded oligonucleotide contains a ligand tethered to an altered or non-natural nucleobase. In certain embodiments, both of the oligonucleotide strands comprising the double-stranded oligonucleotide independently contain a ligand tethered to an altered or non-natural nucleobase. In certain embodiments, the oligonucleotide strands comprise at least one modified sugar moiety. Another aspect of the present invention relates to a single-stranded oligonucleotide comprising at least one ligand tethered to an altered or non-natural nucleobase. In certain embodiments, the non-natural nucleobase is difluorotolyl, nitropyrrolyl, or nitroimidazolyl. In certain embodiments, the ligand is a steroid or aromatic compound. In certain embodiments, the ribose sugar moiety that occurs naturally in nucleosides is replaced with a hexose sugar, polycyclic heteroalkyl ring, or cyclohexenyl group. In certain embodiments, at least one phosphate linkage in the oligonucleotide has been replaced with a phosphorothioate linkage.

  本发明的一个方面涉及一种双链寡核苷酸，其中至少一个配体被系在改变或非天然核碱基上。在某些实施例中，非天然核碱基是二氟基甲苯基、硝基吡咯基或硝基咪唑基。在某些实施例中，配体是类固醇或芳香化合物。在某些实施例中，只有双链寡核苷酸中的两个寡核苷酸链之一包含系在改变或非天然核碱基上的配体。在某些实施例中，双链寡核苷酸中的两个寡核苷酸链都独立地包含系在改变或非天然核碱基上的配体。在某些实施例中，寡核苷酸链包括至少一个修饰糖基。本发明的另一个方面涉及一种单链寡核苷酸，其中至少一个配体被系在改变或非天然核碱基上。在某些实施例中，非天然核碱基是二氟基甲苯基、硝基吡咯基或硝基咪唑基。在某些实施例中，配体是类固醇或芳香化合物。在某些实施例中，核苷酸中自然存在的核苷糖被替换为六糖、多环杂基烷基环或环己烯基团。在某些实施例中，寡核苷酸中至少一个磷酸酯键被磷酸硫酯键所替代。
• SYNTHETIC HEPARIN TRISACCHARIDES
  申请人：SEIFERT Joachim

  公开号：US20120208993A1

  公开（公告）日：2012-08-16

  Preparation and use of synthetic trisaccharides useful for the preparation of synthetic heparinoids.

  合成三糖的制备和使用，适用于合成肝素类化合物的制备。
• SYNTHETIC HEPARIN DISACCHARIDES
  申请人：SEIFERT Joachim

  公开号：US20120220759A1

  公开（公告）日：2012-08-30

  Preparation and use of synthetic monosaccharides, disaccharides, trisaccharides, tetrasaccharides and pentasaccharides for use in the preparation of synthetic heparinoids.

  合成单糖、双糖、三糖、四糖和五糖的制备和使用，用于制备合成肝素类化合物。