1,6-dideoxy-L-mannitol | 68832-20-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1,6-dideoxy-L-mannitol
• 英文别名: L-manno-Hexan-2,3,4,5-tetraol；1,6-Didesoxy-L-mannit；(2S,3S,4S,5S)-hexane-2,3,4,5-tetrol
• CAS: 68832-20-2
• 化学式: C₆H₁₄O₄
• 分子量: 150.175
• InChiKey: TZQPAZWGRJYTLN-BXKVDMCESA-N

物化性质

• 沸点：
  358.2±37.0 °C(Predicted)
• 密度：
  1.260±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.5
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  80.9
• 氢给体数：
  4
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1,6-dideoxy-L-mannitol 在 盐酸 、 苯甲醛 作用下， 生成 O²,O⁴;O³,O⁵-((Ξ,Ξ)-dibenzylidene)-1,6-dideoxy-L-mannitol 、 alkaline earth salt of/the/ methylsulfuric acid
  参考文献：
  名称：

  The Preparation of 1,6-Didesoxy-D-altritol, 1,6-Didesoxygalactitol and 1,6-Didesoxy-L-mannitol¹

  摘要：

  DOI：

  10.1021/ja01137a039
• 作为产物：
  描述：

  L-rhamnose diethyl dithioacetal 在 乙醇 、 镍 作用下， 生成 1,6-dideoxy-L-mannitol
  参考文献：
  名称：

  THE SYNTHESIS OF ω -DEOXY- ω -S-ETHYL-POLYOLS

  摘要：

  使用有限量的老化Raney镍催化剂处理醛糖二乙硫缩醛，导致一个硫乙基基团的还原裂解。因此，已经合成了D-半乳糖醇、L-阿拉伯醇、L-鼠李醇和D-葡萄糖醇的1-去氧-1-S-乙基衍生物，并证明了它们的结构。通过6-去氧-6-S-乙基-D-半乳糖的硼氢化物还原制备了1-去氧-1-S-乙基-L-半乳糖。

  DOI：

  10.1139/v58-027

文献信息

• CLASS- AND ISOFORM-SPECIFIC HDAC INHIBITORS AND USES THEREOF
  申请人：President and Fellows of Harvard College

  公开号：US20150307444A1

  公开（公告）日：2015-10-29

  HDAC inhibitors of the general formula (I) and (II) and pharmaceutically acceptable salts thereof, as described herein, are useful as inhibitors of histone deacetylases or other deacetylases, and thus are useful for the treatment of various diseases and disorders associated with acetylase/deacetylase activity as described herein (e.g., cancer). In certain embodiments, the compounds of the invention selectively target either a class or isoform of the HDAC family. Another aspect of the invention provides an assay for determining the inhibitory effect of a test compound on an HDAC protein comprising: incubating the HDAC protein with a substrate of general formula (IIIc) in the presence of a test compound; and determining the activity of the HDAC protein.

  本发明提供的通式（I）和（II）的HDAC抑制剂及其药学上可接受的盐，作为组蛋白去乙酰化酶或其他去乙酰化酶的抑制剂，因此可用于治疗与去乙酰化酶活性相关的各种疾病和障碍，如本文所述（例如癌症）。在某些实施例中，本发明的化合物有选择性地靶向HDAC家族的某个类别或亚型。本发明的另一方面提供了一种用于确定试验化合物对HDAC蛋白的抑制作用的测定方法，包括：在试验化合物的存在下，将HDAC蛋白与通式（IIIc）的底物孵育，并确定HDAC蛋白的活性。
• The Preparation of 1,6-Didesoxy-D-altritol, 1,6-Didesoxygalactitol and 1,6-Didesoxy-L-mannitol¹
  作者：Emmanuel Zissis、Nelson K. Richtmyer

  DOI：10.1021/ja01137a039

  日期：1952.9
• Process for Producing Carbon-Reduced Aldose Compounds
  申请人：Okitsa Mitsuhito

  公开号：US20090030191A1

  公开（公告）日：2009-01-29

  The present invention provides a process capable of industrially producing 5-deoxy-L-arabinose, important as a raw material for the production of sapropterin useful as a therapeutic agent for atypical hyperphenylalaninemia, satisfactorily efficiently even with a simple production apparatus. Provided is the process for producing 5-deoxy-L-arabinose characterized by including: reacting L-rhamnose with a C 11-16 straight chain alkyl mercaptan compound in the presence of an acid catalyst to prepare L-rhamnose dialkylmercaptal; subjecting then the obtained compound to an oxidation reaction to prepare a sulfonyl derivative; and subjecting then the sulfonyl derivative to a carbon-reduction reaction to prepare 5-deoxy-L-arabinose. The present production process can also be applied to a process for producing compounds obtained by removing one carbon atom from other aldol compounds, and thus the present invention provides a general process for producing compounds obtained by reducing the number of carbon atoms from aldose compounds.
• US9540317B2
  申请人：——

  公开号：US9540317B2

  公开（公告）日：2017-01-10
• Baggett et al., Journal of the Chemical Society, 1965, p. 3401,3403
  作者：Baggett et al.

  DOI：——

  日期：——