4-(2-methoxyphenyl)-5(3)-methyl-1H-pyrazole | 647825-31-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-(2-methoxyphenyl)-5(3)-methyl-1H-pyrazole
• 英文别名: 4-(2-Methoxyphenyl)-3-Methyl-1H-Pyrazole；4-(2-methoxyphenyl)-5-methyl-1H-pyrazole
• CAS: 647825-31-8
• 化学式: C₁₁H₁₂N₂O
• mdl: MFCD00179141
• 分子量: 188.229
• InChiKey: GZVVCGQIGNINSL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.181
• 拓扑面积：
  37.9
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-Dimethylaminomethylene-1-(2-methoxyphenyl)-2-propanone 在 对甲苯磺酸 、 硫酸肼 作用下， 反应 6.0h， 以92%的产率得到4-(2-methoxyphenyl)-5(3)-methyl-1H-pyrazole
  参考文献：
  名称：

  An efficient solvent-free synthesis of NH-pyrazoles from β-dimethylaminovinylketones and hydrazine on grinding

  摘要：

  A series of NH-pyrazoles was efficiently synthesized from the reaction of beta-dimethylaminovinylketones ([(RC)-C-1(O)C(R-2)=CHN(Me-2)], where R-1 = Me, Ph, 3-MeO-Ph, 4-Me-Ph, 4-MeO-Ph, 4-F-Ph, 4-Cl-Ph, 4-Br-Ph, 4-O2N-Ph, fur-2-yl, thien-2-yl; R-2 = H, 2-MeO-Ph; R-1, R-2 = -(CH2)(3)C(O)-) and hydrazine sulfate in solid state on grinding in the presence of p-toluenesulfonic acid (PTSA). Most of the reactions proceeded smoothly at room temperature under solvent-free conditions. In comparison with the classical reaction conditions, which employ molecular solvent (ethanol), this new synthetic method has the advantages of shorter times, higher yields, mild reaction conditions as well as being environmentally friendly. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.04.038

文献信息

• Biaryloxymethylarenecarboxylic acids as glycogen synthase activators
  申请人：Gillespie Paul

  公开号：US20060122256A1

  公开（公告）日：2006-06-08

  The present invention relates to compounds of formula (I) wherein Ar, Ar 2 , R 2 , R 3 , R 4 , m, p and s are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases that are associated with the activation of the glycogen synthase enzyme, such as diabetes.

  本发明涉及以下式(I)的化合物，其中Ar、Ar2、R2、R3、R4、m、p和s如描述和索赔中所定义，并且其药学上可接受的盐。这些化合物可用于治疗和/或预防与糖原合成酶激活相关的疾病，如糖尿病。