4-Methyl-8-phenoxy-1-(4-phenoxyphenyl)-2,3-dihydropyrrolo[3,2-c]quinoline

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4-Methyl-8-phenoxy-1-(4-phenoxyphenyl)-2,3-dihydropyrrolo[3,2-c]quinoline
• 化学式: C₃₀H₂₄N₂O₂
• 分子量: 444.5
• InChiKey: LGEJEOSMEBYTCO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.4
• 重原子数：
  34
• 可旋转键数：
  5
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  34.6
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• TOPICAL FORMULATIONS
  申请人：BECK Petra Helga

  公开号：US20100093691A1

  公开（公告）日：2010-04-15

  There is provided topical pharmaceutical compositions comprising compounds of formula I wherein R 1 , R 2 , R 3 and X have meanings given in the description. These compositions can be used to treat microbial infections and to kill clinically latent microorganisms.

  提供了一种含有I式化合物的局部制药组合物，其中R1、R2、R3和X的含义在说明中给出。这些组合物可用于治疗微生物感染并杀死临床潜伏微生物。
• USE OF PYRROLOQUINOLINE COMPOUNDS TO KILL CLINICALLY LATENT MICROORGANISMS
  申请人：Beck Petra Helga

  公开号：US20120231995A1

  公开（公告）日：2012-09-13

  There is provided the use of compounds of formula I wherein R 1 , R 2 , R 3 and X have meanings given in the description, for the preparation of a medicament for killing clinically latent microorganisms. There is also provided the use of compounds of formula I for treating microbial infections, as well as certain compounds of formula I per se.

  提供了使用式子I中的化合物，其中R1、R2、R3和X的含义在说明中给出，用于制备杀死临床潜伏微生物的药物。还提供了使用式子I中的化合物治疗微生物感染的方法，以及某些式子I中的化合物本身。
• VASODILATOR FOR USE TO TREAT MICROBIAL INFECTIONS
  申请人：Helperby Therapeutics Limited

  公开号：EP3228314A1

  公开（公告）日：2017-10-11

  The present invention relates to the use of one or more compounds selected from the following classes of biologically active agents: an α-adrenergic antagonist, an anthelmintic agent, an antifungal agent, an antimalarial agent, an antineoplastic agent, an antipsychotic agent, an antioxidant, a vasodilator and/or a vitamin, or a pharmaceutically acceptable derivative thereof, for use in the treatment of a microbial infection and in particular for killing multiplying, non-multiplying and/or clinically latent microorganisms associated with such an infection.

  本发明涉及一种或多种选自下列生物活性剂类别的化合物的用途：一种α-肾上腺素能拮抗剂、一种驱虫药、一种抗真菌药、一种抗疟药、一种抗肿瘤药、一种抗精神病药、一种抗氧化剂、一种血管扩张剂和/或一种维生素，或其药学上可接受的衍生物，用于治疗微生物感染，特别是用于杀死与这种感染有关的繁殖的、非繁殖的和/或临床上潜伏的微生物。
• Pharmaceutical composition and method of treating a microbial infection with sulcotidil
  申请人：Hu Yanmin

  公开号：US10265373B2

  公开（公告）日：2019-04-23

  The present invention relates to the use of one or more compounds selected from the following classes of biologically active agents: an a-adrenergic antagonist, an anthelmintic agent, an antifungal agent, an antimalarial agent, an antineoplastic agent, an antipsychotic agent, an antioxidant, a vasodilator and/or a vitamin, or a pharmaceutically acceptable derivative thereof, for use in the treatment of a microbial infection and in particular for killing multiplying, non-multiplying and/or clinically latent microorganisms associated with such an infection.

  本发明涉及一种或多种选自下列生物活性剂类别的化合物的用途：一种肾上腺素能拮抗剂、一种驱虫药、一种抗真菌药、一种抗疟药、一种抗肿瘤药、一种抗精神病药、一种抗氧化剂、一种血管扩张剂和/或一种维生素，或其药学上可接受的衍生物，用于治疗微生物感染，特别是用于杀死与这种感染有关的繁殖的、非繁殖的和/或临床上潜伏的微生物。
• NOVEL COMBINATION AND USE
  申请人：Helperby Therapeutics Limited

  公开号：EP2552440A1

  公开（公告）日：2013-02-06