5,5,6,6,6-pentafluorohexan-1-ol | 58556-45-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 5,5,6,6,6-pentafluorohexan-1-ol
• CAS: 58556-45-9
• 化学式: C₆H₉F₅O
• mdl: MFCD06248629
• 分子量: 192.129
• InChiKey: UEKOJSYLWJADHW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  6

安全信息

• 危险等级：
  IRRITANT

反应信息

• 作为反应物：
  描述：

  5,5,6,6,6-pentafluorohexan-1-ol 、 3-((tert-butyldimethylsilyl)oxy)-5-((4-ethyl-2-(heptan-3-yl)octyl)oxy)-5-oxopentanoic acid 在 4-二甲氨基吡啶 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 9.0h， 生成
  参考文献：
  名称：

  CN114874106

  摘要：

  公开号：

文献信息

• Homogeneous asymmetric hydrogenation catalyst
  申请人：Shimizu Hideo

  公开号：US20090203927A1

  公开（公告）日：2009-08-13

  Provide that a useful catalyst for homogeneous hydrogenation, particularly a catalyst for homogeneous asymmetric hydrogenation for hydrogenation, particularly asymmetric hydrogenation, which is obtainable with comparative ease and is excellent in economically and workability, and a process for producing a hydrogenated compound of an unsaturated compound, particularly an optically active compound using said catalyst with a high yield and optical purity.

  提供一种用于均相氢化的有用催化剂，特别是用于均相不对称氢化的催化剂，特别是不对称氢化的催化剂，该催化剂易于获得，在经济性和可操作性方面表现出色，以及一种使用该催化剂产生不饱和化合物的氢化物的方法，特别是使用高产率和光学纯度的该催化剂产生手性活性化合物。
• PROCESS FOR PRODUCTION OF AMIDES OR LACTAMS
  申请人：Daicel Chemical Industries, Ltd.

  公开号：EP2006283A9

  公开（公告）日：2009-07-15

  An amide or lactam is produced by conducting a rearrangement of a corresponding oxime compound in the presence of a cyclic compound containing a structure represented by following Formula (1) as a ring constituent and a fluorinated alcohol: wherein Z represents a halogen atom or an -OR group, where R represents an organic group. Z is preferably chlorine atom. Exemplary fluorinated alcohols include fluorine-containing branched-chain aliphatic alcohols represented by following Formula (3): wherein Rf1 and Rf2 may be the same as or different from each other and each represent a perfluoroalkyl group having one to eight carbon atoms; and "n" denotes an integer of 0 to 8. According to this process, amides or lactams can be simply produced in high yields without causing large amounts of by-products.

  通过在含有以下式（1）所代表的结构的环组分和氟化醇的存在下对相应的肟化合物进行重排，可以产生酰胺或内酰胺：其中Z代表卤素原子或-OR基团，其中R代表有机基团。Z最好是氯原子。示例氟化醇包括以下式（3）所代表的含氟支链脂肪醇：其中Rf1和Rf2可以相同也可以不同，每个代表具有一至八个碳原子的全氟烷基基团；“n”表示0至8的整数。根据这个过程，可以简单地高产率地生产酰胺或内酰胺，而不产生大量副产物。
• Substituted optically active disphosphine compound
  申请人：Fujiwara Takahiro

  公开号：US20070073065A1

  公开（公告）日：2007-03-29

  Provided is a method for producing an optically active compound, in more detail, for producing an optically active compound by asymmetric hydrogenation in a high yield and asymmetric yield. The present invention also provides a catalyst for asymmetric synthesis for the above production method, especially a catalyst for asymmetric hydrogenation, containing a transition metal complex. Further, the present invention provides a new diphosphine compound useful as a ligand of the above transition metal complex and a new transition metal complex containing the above diphosphine compound. The present invention relates to a diphosphine compound represented by the following formula (1): a transition metal complex using the compound, a catalyst for asymmetric synthesis comprising the above transition metal complex and a method for producing an optically active compound using the above catalyst for asymmetric synthesis.

  提供了一种制备光学活性化合物的方法，更详细地说，是通过高收率和不对称收率的不对称氢化来制备光学活性化合物。本发明还提供了一种用于上述生产方法的不对称合成催化剂，特别是一种包含过渡金属配合物的不对称氢化催化剂。此外，本发明还提供了一种新的二膦化合物，可用作上述过渡金属配合物的配体，以及一种含有上述二膦化合物的新过渡金属配合物。本发明涉及以下式（1）所表示的二膦化合物，使用该化合物的过渡金属配合物，包括上述过渡金属配合物的不对称合成催化剂以及使用上述不对称合成催化剂制备光学活性化合物的方法。
• 17Beta-Alkyl-17Alpha-oxy-estratrienes
  申请人：Bohlmann Rolf

  公开号：US20120157421A1

  公开（公告）日：2012-06-21

  The invention relates to 17β-alkyl-17α-oxy-oestratrienes of the formula (I), to processes for their preparation, to the use of the 17β-alkyl-17α-oxy-oestratrienes for preparing pharmaceuticals and to pharmaceutical preparations comprising these compounds.

  本发明涉及式(I)的17β-烷基-17α-氧基-雌三烯，以及制备它们的方法，使用17β-烷基-17α-氧基-雌三烯制备药物的方法，以及包含这些化合物的药物制剂。
• Method for producing an optically activ beta-amino acid
  申请人：——

  公开号：US20040023344A1

  公开（公告）日：2004-02-05

  The Problem to Be Solved: To provide a producing method of an optically active &bgr;-amino acid useful as intermediate for the production of medicines, agricultural chemicals and physiologically active substances, by means of a catalytic and asymmetric synthesis method of high performance and a high enantiomeric excess, without requiring additional procedures such as introduction and removal of protecting group and so on. Means to Solve the Problems: A producing method of an optically active &bgr;-amino acids which comprises subjecting an enamine to an asymmetric hydrogenation.

  需要解决的问题：提供一种光学活性的β-氨基酸生产方法，作为制药、农药和生理活性物质的中间体，通过高性能和高对映体过量的催化不对称合成方法，而不需要额外的保护基引入和去除等程序。 解决问题的方法：一种生产光学活性β-氨基酸的方法，包括将恩酰胺进行不对称氢化。