5-Bromo-7-chloro-1,2,3,4-tetrahydroquinolin-2-one | 1803611-66-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 5-Bromo-7-chloro-1,2,3,4-tetrahydroquinolin-2-one
• 英文别名: 5-bromo-7-chloro-3,4-dihydro-1H-quinolin-2-one
• CAS: 1803611-66-6
• 化学式: C₉H₇BrClNO
• mdl: MFCD28246371
• 分子量: 260.51
• InChiKey: MYUMFSKXEHZBTN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.222
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• ARYL-SUBSTITUTED DIHYDROQUINOLINONES, THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS
  申请人：Neomed Institute

  公开号：EP3334717B1

  公开（公告）日：2020-07-01
• [EN] ARYL-SUBSTITUTED DIHYDROQUINOLINONES, THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS<br/>[FR] DIHYDROQUINOLINONES SUBSTITUÉES PAR UN GROUPE ARYLE, LEUR PRÉPARATION ET LEUR UTILISATION COMME AGENTS PHARMACEUTIQUES
  申请人：NEOMED INST

  公开号：WO2017024408A1

  公开（公告）日：2017-02-16

  This application relates to aryl-substituted dihydroquinolinones of formula (I), compositions comprising them and their uses in the treatment of diseases and conditions in which inhibition of a bromodomain is indicated. For example, the application relates to aryl-substituted dihydroquinolinones and to their use as bromodomain inhibitors. The present application is also related to the treatment or prevention of proliferative disorders, auto-immune disorders, inflammatory disorders, dermal disorders, and neoplasms, including tumors and/or cancers.