2-(4-propylphenyl)-1-morpholin-4-yl-ethanethione | 643062-81-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(4-propylphenyl)-1-morpholin-4-yl-ethanethione
• 英文别名: 1-(Morpholin-4-yl)-2-(4-propylphenyl)ethane-1-thione；1-morpholin-4-yl-2-(4-propylphenyl)ethanethione
• CAS: 643062-81-1
• 化学式: C₁₅H₂₁NOS
• 分子量: 263.404
• InChiKey: UNJWLCWHFZNPOO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  44.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  吗啉 、 对丙基苯乙酮 在 N-甲基吗啉 、 1,2,3,4,5,6,7,8-八硫杂环辛烷 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 2.0h， 以43%的产率得到2-(4-propylphenyl)-1-morpholin-4-yl-ethanethione
  参考文献：
  名称：

  WILLGERODT-KINDLER'S MICROWAVE-ENHANCED SYNTHESIS OF THIOAMIDE DERIVATIVES

  摘要：

  The Willgerodt-Kindler reaction was applied to a series of aromatic aldehydes and ketones. The reactions were performed in a dipolar aprotic solvent (mainly DMF) in the presence of a base catalyst (4-methylmorpholine) and utilized microwave (mw) irradiation. The pulsed mw technique rather than the continuous irradiation was preferred because it limited side reactions and hydrogen sulfide production. While not always superior to the thermal activation of the reaction, the procedure involving repetitive short pulses of microwave irradiation was found to be faster and result in consistently cleaner products. The technique can be easily applied in a fast parallel synthesis process.

  DOI：

  10.1080/10426500490466995

文献信息

• Novel pyran derivative, its preparation method, liquid crystal composition and liquid crystal display device comprising the same
  申请人：Choi Bum-Gyu

  公开号：US20100059710A1

  公开（公告）日：2010-03-11

  The present invention relates to a pyran derivative which manifests appropriate refractive anisotropy (optical anisotropy) and liquid crystal transition temperature and excellent dielectric anisotropy, and has excellent compatibility with various liquid crystal compounds, and thus, can be preferably used for the formation of a liquid crystal layer of a liquid crystal display device, its preparation method, a liquid crystal composition and liquid crystal display device comprising the same.
• US7968003B2
  申请人：——

  公开号：US7968003B2

  公开（公告）日：2011-06-28
• WILLGERODT-KINDLER'S MICROWAVE-ENHANCED SYNTHESIS OF THIOAMIDE DERIVATIVES
  作者：Jacques H. Poupaert、Sandro Duarte、Evelina Colacino、Patrick Depreux、Christopher R. McCurdy、Didier L. Lambert

  DOI：10.1080/10426500490466995

  日期：2004.10.1

  The Willgerodt-Kindler reaction was applied to a series of aromatic aldehydes and ketones. The reactions were performed in a dipolar aprotic solvent (mainly DMF) in the presence of a base catalyst (4-methylmorpholine) and utilized microwave (mw) irradiation. The pulsed mw technique rather than the continuous irradiation was preferred because it limited side reactions and hydrogen sulfide production. While not always superior to the thermal activation of the reaction, the procedure involving repetitive short pulses of microwave irradiation was found to be faster and result in consistently cleaner products. The technique can be easily applied in a fast parallel synthesis process.