(12Z,23Z)-hexacosadienoic acid | 1538661-44-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (12Z,23Z)-hexacosadienoic acid
• 英文别名: (12Z,23Z)-hexacosa-12,23-dienoic acid
• CAS: 1538661-44-7
• 化学式: C₂₆H₄₈O₂
• 分子量: 392.666
• InChiKey: GOZVVKNPCINCEP-GEUUWGDVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.6
• 重原子数：
  28
• 可旋转键数：
  22
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.81
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1,12-十二烷二醇 在 咪唑 、 四丁基氟化铵 、 sodium hexamethyldisilazane 、 pyridinium chlorochromate 作用下， 以 四氢呋喃 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 生成 (12Z,23Z)-hexacosadienoic acid
  参考文献：
  名称：

  Synthesis of long-chain fatty acid derivatives as a novel anti-Alzheimer’s agent

  摘要：

  In order to develop new drugs for Alzheimer's disease, we prepared 17 fatty acid derivatives with different chain lengths and different numbers and positions of double bonds by using Wittig reaction and stereospecific hydrogenation of triple bonds as key reactions. Among them, (4Z,15Z)-octadecadienoic acid (10) and (23Z,34Z)-heptatriacontadienoic acid (16) showed the most potent neurite outgrowth activities on A beta(25-35)-treated rat cortical neurons, which activities were comparable to that of a positive control, NGF. Both fatty acids 10 and 16 possess two (Z)-double bonds at the n-3 and n-14 positions, which might be important for the neurite outgrowth activity. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2013.12.008