5-Chloro-7-[(4-chlorophenyl)(morpholin-4-yl)methyl]quinolin-8-ol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 5-Chloro-7-[(4-chlorophenyl)(morpholin-4-yl)methyl]quinolin-8-ol
• 英文别名: 5-chloro-7-[(4-chlorophenyl)-morpholin-4-ylmethyl]quinolin-8-ol
• 化学式: C₂₀H₁₈Cl₂N₂O₂
• 分子量: 389.3
• InChiKey: DCTAYAHGXNQCJD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  45.6
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Novel Quinoline-Hepcidine Antagonists
  申请人：Dürrenberger Franz

  公开号：US20120196853A1

  公开（公告）日：2012-08-02

  The present invention relates to novel hepcidin antagonists of the general formula (I), pharmaceutical compositions comprising them and the use thereof as medicaments, in particular for treatment of disorders in iron metabolism, such as, in particular, iron deficiency diseases and anaemias, in particular anaemias in connection with chronic inflammatory diseases (ACD: anaemia of chronic disease and AI: anaemia of inflammation).

  本发明涉及一种新型的肝铁蛋白拮抗剂，其一般式为(I)，包括它们的药物组合物以及将其用作药物的用途，特别是用于治疗铁代谢紊乱的疾病，如特别是铁缺乏病和贫血，特别是与慢性炎症性疾病相关的贫血（ACD：慢性疾病贫血和AI：炎症性贫血）。
• NEUE CHINOLIN-HEPCIDIN-ANTAGONISTEN
  申请人：VIFOR (INTERNATIONAL) AG

  公开号：EP2467361A1

  公开（公告）日：2012-06-27
• FLAVIVIRUS INHIBITORS AND METHODS FOR THEIR USE
  申请人：Padmanabhan Radhakrishnan

  公开号：US20110224207A1

  公开（公告）日：2011-09-15

  Methods of treating, preventing, and/or ameliorating a Flavivirus infection in a subject are disclosed. The methods comprise administering to the subject a therapeutically effective amount of a Flavivirus inhibitor, e.g., a Flavivirus serine protease inhibitor. These methods are useful in treating, preventing, and/or ameliorating Flavivurs infections such as, for example, West Nile Virus, Dengue Virus, and Japanese Encephalitis Virus.
• Flavivirus Inhibitors and Methods of Their Use
  申请人：Padmanabhan Radhakrishnan

  公开号：US20140038962A1

  公开（公告）日：2014-02-06

  Methods of treating, preventing, and/or ameliorating a Flavivirus infection in a subject are disclosed. The methods comprise administering to the subject a therapeutically effective amount of a Flavivirus inhibitor, e.g., a Flavivirus serine protease inhibitor. These methods are useful in treating, preventing, and/or ameliorating Flavivirus infections such as, for example, West Nile Virus, Dengue Virus, and Japanese Encephalitis Virus.
• US8563580B2
  申请人：——

  公开号：US8563580B2

  公开（公告）日：2013-10-22