4-(1H-benzimidazol-2-yloxy)aniline | 1018987-29-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-(1H-benzimidazol-2-yloxy)aniline
• CAS: 1018987-29-5
• 化学式: C₁₃H₁₁N₃O
• mdl: MFCD12856975
• 分子量: 225.25
• InChiKey: WQRJYRFQNBEIOS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  63.9
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-(甲基磺酰基)-(9ci)-1H-苯并咪唑 、 对氨基苯酚 在 三乙胺 作用下， 反应 15.0h， 生成 4-(1H-benzimidazol-2-yloxy)aniline 、 4-(1H-benzimidazol-2-ylamino)phenol
  参考文献：
  名称：

  An efficient method to access 2-substituted benzimidazoles under solvent-free conditions

  摘要：

  An expeditious method to access 2-substituted benzimidazoles was developed. Both aromatic (phenols, anilines, and thiophenols) and alkyl nucleophiles (amines and thiols) react with 2-methylsulfonyl benzimidazole under solvent-free conditions to generate a variety of 2-substituted benzimidazoles. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.01.100

文献信息

• An efficient method to access 2-substituted benzimidazoles under solvent-free conditions
  作者：Ping Lan、F. Anthony Romero、Threshia S. Malcolm、Benjamin D. Stevens、Dariusz Wodka、Gergely M. Makara

  DOI：10.1016/j.tetlet.2008.01.100

  日期：2008.3

  An expeditious method to access 2-substituted benzimidazoles was developed. Both aromatic (phenols, anilines, and thiophenols) and alkyl nucleophiles (amines and thiols) react with 2-methylsulfonyl benzimidazole under solvent-free conditions to generate a variety of 2-substituted benzimidazoles. (c) 2008 Elsevier Ltd. All rights reserved.