5-[4-(dimethylamino)-3-nitrophenyl]-2,2-dimethyl-2,3,5,6-tetrahydrobenzo[a]phenanthridin-4(1H)-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 5-[4-(dimethylamino)-3-nitrophenyl]-2,2-dimethyl-2,3,5,6-tetrahydrobenzo[a]phenanthridin-4(1H)-one
• 英文别名: 5-[4-(dimethylamino)-3-nitrophenyl]-2,2-dimethyl-1,3,5,6-tetrahydrobenzo[a]phenanthridin-4-one
• 化学式: C27H27N3O3
• 分子量: 441.5
• InChiKey: HJYQHNZJOCPURW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  33
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  78.2
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Inhibition of glutaminase C
  申请人：Cornell University

  公开号：US10987317B2

  公开（公告）日：2021-04-27

  The present invention relates to a method of reducing the production of glutamate from glutamine by glutaminase C in a cell or tissue. The method involves inhibiting glutaminase C activity in the cell or tissue under conditions effective to reduce production of glutamate from glutamine. Compounds for carrying out this method are also disclosed.

  本发明涉及一种减少细胞或组织中谷氨酰胺酶 C 由谷氨酰胺产生谷氨酸的方法。该方法包括在有效减少谷氨酰胺产生谷氨酸的条件下抑制细胞或组织中谷氨酰胺酶 C 的活性。还公开了用于实施该方法的化合物。
• INHIBITIONS OF GLUTAMINASE C
  申请人：Cerione Richard A.

  公开号：US20120220610A1

  公开（公告）日：2012-08-30

  The present invention relates to a method of reducing the production of glutamate from glutamine by glutaminase C in a cell or tissue. The method involves inhibiting glutaminase C activity in the cell or tissue under conditions effective to reduce production of glutamate from glutamine. Compounds for carrying out this method are also disclosed.
• ACTIVATING PHOSPHORYLATION SITE ON GLUTAMINASE C
  申请人：Cerione Kristin Wilson

  公开号：US20130252983A1

  公开（公告）日：2013-09-26

  A method of reducing the production of glutamate from glutamine by glutaminase C in a cell or tissue. The method involves inhibiting activating phosphorylation of glutaminase C under conditions effective to reduce production of glutamate from glutamine. Methods for treating or preventing a condition mediated by the activating phosphorylation of glutaminase C, detecting a condition mediated by the activating phosphorylation of glutaminase C, and screening for compounds capable of treating or preventing cancer are also disclosed.
• METHODS FOR TREATING POLYCYSTIC KIDNEY DISEASE
  申请人：Skolnik Edward

  公开号：US20150065486A1

  公开（公告）日：2015-03-05

  Methods for treating autosomal dominant polycystic kidney disease (ADPKD) are described herein. More particularly, methods described herein relate generally to administering glutaminase1 inhibitors to subjects afflicted with ADPKD. Accordingly, the use and application of compounds or agents that inhibit glutaminase1 for treating ADPKD or for use in a medicament for treating ADPKD are encompassed herein.
• INHIBITION OF GLUTAMINASE C
  申请人：Cornell University

  公开号：US20200206149A1

  公开（公告）日：2020-07-02

  The present invention relates to a method of reducing the production of glutamate from glutamine by glutaminase C in a cell or tissue. The method involves inhibiting glutaminase C activity in the cell or tissue under conditions effective to reduce production of glutamate from glutamine. Compounds for carrying out this method are also disclosed.