4-chloro-2-[1]naphthyl-quinoline | 108014-72-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4-chloro-2-[1]naphthyl-quinoline
• 英文别名: 4-Chlor-2-[1]naphthyl-chinolin；4-Chloro-2-naphthalen-1-ylquinoline
• CAS: 108014-72-8
• 化学式: C₁₉H₁₂ClN
• 分子量: 289.764
• InChiKey: XIVXKJQKJUBGLW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  21
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  (E/Z)-N-phenyl-1-naphthimidoyl chloride 在 氯仿 、 paraffin 、 三氯氧磷 作用下， 生成 4-chloro-2-[1]naphthyl-quinoline
  参考文献：
  名称：

  Staskun, Journal of the South African Chemical Institute, 1956, vol. 9, p. 89

  摘要：

  DOI：

文献信息

• ANTAGONISM OF IMMUNOSTIMULATORY CPG-OLIGONUCLEOTIDES BY 4-AMINOQUINOLINES AND OTHER WEAK BASES
  申请人：UNIVERSITY OF IOWA RESEARCH FOUNDATION

  公开号：EP1377554A1

  公开（公告）日：2004-01-07
• QUINOLINES DERIVATIVES AS NOVEL ANTICANCER AGENTS
  申请人：Genoscience Pharma SAS

  公开号：EP2976333A1

  公开（公告）日：2016-01-27
• US6479504B1
  申请人：——

  公开号：US6479504B1

  公开（公告）日：2002-11-12
• [EN] ANTAGONISM OF IMMUNOSTIMULATORY CPG-OLIGONUCLEOTIDES BY 4-AMINOQUINOLINES AND OTHER WEAK BASES<br/>[FR] ANTAGONISME DES OLIGONUCLEOTIDES CPG IMMUNOSTIMULATEURS PAR DES 4-AMINOQUINOLINES ET AUTRES BASES FAIBLES
  申请人：UNIV IOWA STATE RES FOUND

  公开号：WO2000076982A1

  公开（公告）日：2000-12-21

  The present invention relates generally to the field of immunology. More particularly it concerns compositions and methods for inhibiting stimulation of the immune system. The compounds and methods comprise compounds that are analogs and derivatives of chloroquine, such as 4-aminoquinolines, and other weak bases. They can be used in preventative and therapeutic treatments of autoimmune diseases and phenomena, transplant rejection such as host-versus-graft disease, and sepsis.
• [EN] QUINOLINES DERIVATIVES AS NOVEL ANTICANCER AGENTS<br/>[FR] DÉRIVÉS DE QUINOLINES EN TANT QUE NOUVEAUX AGENTS ANTICANCÉREUX
  申请人：GENOSCIENCE PHARMA

  公开号：WO2014147611A1

  公开（公告）日：2014-09-25

  The invention provides quinoline derivatives, their manufacture, pharmaceutical compositions containing them, and their use as medicaments. The active compounds of the present invention are useful for the treatment of proliferative neoplastic and nonneoplastic diseases.