(E)-3-[3-[(2,2-dichloroacetyl)amino]-4-[2-(diethylamino)ethylsulfanyl]phenyl]-N-hydroxyprop-2-enamide

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: (E)-3-[3-[(2,2-dichloroacetyl)amino]-4-[2-(diethylamino)ethylsulfanyl]phenyl]-N-hydroxyprop-2-enamide
• 化学式: C₁₇H₂₃Cl₂N₃O₃S
• 分子量: 420.4
• InChiKey: FDYCCWDPHWOAPH-SOFGYWHQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  26
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  107
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• NOVEL HISTONE DEACETYLASE INHIBITORS, PROCESS FOR PREPARATION AND USES THEREOF
  申请人：Yu Niefang

  公开号：US20110218221A1

  公开（公告）日：2011-09-08

  The present invention relates to compounds represented by formula (I) or composition comprising at least one of such compounds, which are inhibitors of histone deacetylase. The detailed description of these compounds is disclosed in the Description. These compounds and the composition comprising the same may be useful as medicaments for the treatment of proliferative disorders as well as other diseases involving, relating to or associated with enzymes having histone deacetylase (HDAC) activities.

  本发明涉及化学式(I)所代表的化合物或含有这些化合物中至少一种的组合物，这些化合物是组蛋白去乙酰化酶的抑制剂。这些化合物的详细描述在说明书中公开。这些化合物和含有它们的组合物可能作为药物用于治疗增生性疾病以及涉及、与或相关的组蛋白去乙酰化酶（HDAC）活性的其他疾病。
• HISTONE DEACETYLASE INHIBITOR, COMPOSITION AND USE THEREOF
  申请人：Zhejiang Hisun Pharmaceutical Co. Ltd.

  公开号：EP2208721A1

  公开（公告）日：2010-07-21

  The present invention relates to compounds represented by formula (I) or composition comprising at least one of such compounds, which are inhibitors of histone deacetylase. The detailed description of these compounds is disclosed in the Description. These compounds and the composition comprising the same may be useful as medicaments for the treatment of proliferative disorders as well as other diseases involving, relating to or associated with enzymes having histone deacetylase (HDAC) activities.

  本发明涉及式（I）代表的化合物或包含至少一种此类化合物的组合物，它们是组蛋白去乙酰化酶的抑制剂。这些化合物的详细描述见说明书。这些化合物和包含这些化合物的组合物可用作治疗增殖性疾病以及其他涉及、与具有组蛋白去乙酰化酶（HDAC）活性的酶有关或相关的疾病的药物。
• US8921424B2
  申请人：——

  公开号：US8921424B2

  公开（公告）日：2014-12-30