7-((甲基乙氧基亚膦酰)氧基)-1-甲基喹啉鎓 | 95230-44-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 7-((甲基乙氧基亚膦酰)氧基)-1-甲基喹啉鎓
• 英文名称: 7-[Ethoxy(methyl)phosphoryl]oxy-1-methylquinolin-1-ium;iodide
• CAS: 95230-44-7
• 化学式: C13H17INO3P
• 分子量: 393.16
• InChiKey: SZDLDJBIJTUFBS-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -0.09
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  39.4
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Acetylcholinesterase-Fc domain fusion protein
  申请人：The Israel Institute of Biological Research (IIBR)

  公开号：US10106785B2

  公开（公告）日：2018-10-23

  Fusion polypeptides are provided including modified human Acetylcholinesterase conjugated to the Fc region of an immunoglobulin. Methods of preparing these polypeptide constructs and uses thereof as scavenging agents of organophosphate compounds are described.

  本研究提供了融合多肽，包括与免疫球蛋白 Fc 区连接的修饰人乙酰胆碱酯酶。文中描述了制备这些多肽构建体的方法及其作为有机磷化合物清除剂的用途。
• Decontamination system and method of decontamination
  申请人：——

  公开号：US20030049187A1

  公开（公告）日：2003-03-13

  A decontamination system including an absorptive/absorptive activated carbon felt pad saturated with a non-hazardous CWA decontamination solvent as nonspecific means of decontaminating equipment and open-wounds is provided. The entire system preferably includes an absorbent pad and decontamination fluid in a sealed, disposable plastic packet. The system is thus a simple and immediate means of personal decontamination. The decontamination fluid and the absorbent pads of the present invention are non-hazardous, nontoxic, and nonflammable. The system is thus safe, and able to readily meet with FDA approval. The system is small and easily corrected in a field pack or other means and can be safely disposed of after use. The same system is also useable at casualty receiving stations to decontaminate patients and/or equipment. The open-wound decontamination system has the ability to absorb CWA into a non-hazardous fluid, and the ability to adsorb CWA from the fluid onto a solid adsorbent.

  提供了一种去污系统，包括一个吸附/吸收性活性炭毡垫，蘸有非危险性 CWA 去污溶剂，作为去污设备和开放性伤口的非特异性手段。整个系统最好包括密封的一次性塑料包中的吸附垫和去污液。因此，该系统是一种简单而直接的个人去污手段。本发明的去污液和吸收垫是无害、无毒和不易燃的。因此，该系统是安全的，能够随时获得美国食品及药物管理局的批准。该系统体积小，易于在野外包装或其他方式中进行校正，使用后可安全处置。该系统还可用于伤员接收站，对病人和/或设备进行洗消。 开放式伤口净化系统能够将 CWA 吸收到非危险液体中，还能将液体中的 CWA 吸附到固体吸附剂上。
• Rapid method to make OP detoxifying sponges composed of multiple immobilized enzymes of cholinesterases and OP hydrolases and oximes as reactivators
  申请人：——

  公开号：US20030113902A1

  公开（公告）日：2003-06-19

  A material comprising a porous support and a plurality of enzymes for the removal, decontamination or neutralization of hazardous chemicals such as OP compounds is disclosed. The material may be used on a variety of surfaces, including natural, synthetic and biological surfaces such as skin and other delicate membranes. Also disclosed is a process of making the material, kits and various methods and reactivation devices for reactivating the enzymatic activity of the material.

  公开了一种由多孔支架和多种酶组成的材料，用于去除、净化或中和 OP 化合物等危险化学品。该材料可用于各种表面，包括天然表面、合成表面和生物表面，如皮肤和其他娇嫩的薄膜。此外，还公开了该材料的制造工艺、试剂盒以及用于重新激活该材料酶活性的各种方法和重新激活装置。
• EXPRESSION OF ENZYMATICALLY ACTIVE RECOMBINANT HUMAN ACETYLCHOLINESTERASE AND USES THEREOF
  申请人：BIO-TECHNOLOGY GENERAL CORPORATION

  公开号：EP0591472A1

  公开（公告）日：1994-04-13
• DIFFERENTIALLY ACTING OP DETOXIFYING SPONGES
  申请人：U.S. Army Medical Research and Materiel Command

  公开号：EP1175453A2

  公开（公告）日：2002-01-30