N~2~,N~2~-diethyl-3-methyl-5-({[2-(5-methylfuran-2-yl)quinolin-4-yl]carbonyl}amino)thiophene-2,4-dicarboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N~2~,N~2~-diethyl-3-methyl-5-({[2-(5-methylfuran-2-yl)quinolin-4-yl]carbonyl}amino)thiophene-2,4-dicarboxamide
• 英文别名: 2-N,2-N-diethyl-3-methyl-5-[[2-(5-methylfuran-2-yl)quinoline-4-carbonyl]amino]thiophene-2,4-dicarboxamide
• 化学式: C₂₆H₂₆N₄O₄S
• 分子量: 490.6
• InChiKey: OMSBEWCLPPPUMH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  35
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  147
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• Thiophens and Their Use as Anti-Tumor Agents
  申请人：Ward John

  公开号：US20090143411A1

  公开（公告）日：2009-06-04

  The present invention provides novel compounds and pharmaceutical compositions thereof, as well as methods for using the compounds and pharmaceutical compositions for treating tumors. Examples of specific tumor types that the compounds may be used to treat include, but are not limited to sarcomas, melanomas, neuroblastomas, carcinomas (including but not limited to lung, renal cell, ovarian, liver, bladder, and pancreatic carcinomas), and mesotheliomas.