IdoA(a1-4)GlcNAc

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: IdoA(a1-4)GlcNAc
• 英文别名: (2R,3S,4S,5R,6R)-6-[(2R,3S,4R,5R)-5-acetamido-4,6-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid
• 化学式: C₁₄H₂₃NO₁₂
• 分子量: 397.33
• InChiKey: CTOILUIGUWLSNU-FATYIBEYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.5
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  216
• 氢给体数：
  8
• 氢受体数：
  12

反应信息

• 作为产物：
  描述：

  在 palladium on activated charcoal 、 氢气 作用下， 生成 IdoA(a1-4)GlcNAc
  参考文献：
  名称：

  OLIGOSACCHARIDE LINKER, LINKER-PAYLOAD COMPRISING THE SAME AND GLYCAN CHAIN-REMODELED ANTIBODY-DRUG CONJUGATE, PREPARATION METHODS AND USES THEREOF

  摘要：

  The present disclosure further relates to a linker-payload compound including an oligosaccharide group, especially a disaccharide group, where the oligosaccharide group is linked to the remainder of the compound by an amide bond. The present disclosure further relates to an antibody-drug conjugate (ADC) containing the linker-payload compound, where the glycan chain in an antibody is remodeled with the oligosaccharide moiety in the linker-payload compound. The present disclosure further relates to preparation methods and use of the above-mentioned substances.

  公开号：

  US20240082419A1

文献信息

• OLIGOSACCHARIDE LINKER, LINKER-PAYLOAD COMPRISING THE SAME AND GLYCAN CHAIN-REMODELED ANTIBODY-DRUG CONJUGATE, PREPARATION METHODS AND USES THEREOF
  申请人：GENEQUANTUM HEALTHCARE CO., LTD.

  公开号：US20240082419A1

  公开（公告）日：2024-03-14

  The present disclosure further relates to a linker-payload compound including an oligosaccharide group, especially a disaccharide group, where the oligosaccharide group is linked to the remainder of the compound by an amide bond. The present disclosure further relates to an antibody-drug conjugate (ADC) containing the linker-payload compound, where the glycan chain in an antibody is remodeled with the oligosaccharide moiety in the linker-payload compound. The present disclosure further relates to preparation methods and use of the above-mentioned substances.