9-Deoxy-hydro-chinin | 26315-79-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 9-Deoxy-hydro-chinin
• 英文别名: Deoxy-dihydro-chinin；Desoxy-dihydro-chinin；Deoxy-dihydro-chinidin；6'-methoxy-10,11-dihydro-cinchonane；6'-Methoxy-10,11-dihydro-cinchonan；4-[(5-Ethyl-1-azabicyclo[2.2.2]octan-2-yl)methyl]-6-methoxyquinoline；4-[(5-ethyl-1-azabicyclo[2.2.2]octan-2-yl)methyl]-6-methoxyquinoline
• CAS: 26315-79-7；51152-57-9；51152-58-0；95782-85-7
• 化学式: C₂₀H₂₆N₂O
• 分子量: 310.439
• InChiKey: GINOTSNLGTZRNJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  25.4
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Asymmetric aldol additions using bifunctional cinchona-alkaloid-based catalysts
  申请人：Deng Li

  公开号：US20070112199A1

  公开（公告）日：2007-05-17

  One aspect of the present invention relates to asymmetric catalytic nitroaldol (Henry) reactions with ketones as the electrophilic component. In one embodiment, the present invention relates to asymmetric nitroaldol reactions with α-keto esters catalyzed by a new C6′-OH cinchona alkaloid catalyst. In certain embodiments, this reaction is operationally simple and affords high enantioselectivity as well as good to excellent yield for an exceptionally broad range of α-keto esters.