4-Methylcyclohexan-1-on-2-essigsaeure | 58925-89-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-Methylcyclohexan-1-on-2-essigsaeure
• 英文别名: (5-methyl-2-oxo-cyclohexyl)-acetic acid；(5-Methyl-2-oxo-cyclohexyl)-essigsaeure；2-(5-Methyl-2-oxocyclohexyl)acetic acid
• CAS: 58925-89-6
• 化学式: C₉H₁₄O₃
• 分子量: 170.208
• InChiKey: PTUITBRHHUBRNJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-Methylcyclohexan-1-on-2-essigsaeure 在 盐酸 、 乙醚 、 乙醇 作用下， 生成 (2-hydroxy-5-methyl-2-phenyl-cyclohexyl)-acetic acid ethyl ester
  参考文献：
  名称：

  Monoclonal anti-EGFreceptor antibody (ior-R3) pharmacokinetic study in tumor bearing nude mice: Role of the receptor-mediated endocytosis on drug clearance

  摘要：

  With the purpose of describing the MAb ior-R3's kinetic behavior in disease state, this paper is focused on the study of this response using a human cancer (lung carcinoma cell line, H 125) bearing nude mice animal model. This MAb was administered by a single 16 mg/Kg intravenous bolus dose and the blood samples were collected at several times ranging from 0 to 72 hours for serum drug quantification. The experimental data set was best fitted using a classical two- compartment mammilary pharmacokinetic (PK) model and the corresponding PK parameters were determined. Comparativel, the analysis of the more relevant physiologically-based PK parameters showed a significant enhancing of clearance as compound with the earlier reported study on healthy mice, increasing from 0.09 to 0.19 mL/h (p<0.01). However, the corresponding distribution volumes don't seem to be altered by the tumor xenograft. We conclude that all of these evidences suggest a possible mechanism of receptor- mediated endocytosis (RME) as a major cause of this increased drug clearance which also contributed to the faster decrease of the drug disposition.

  DOI：

  10.1007/bf03190423
• 作为产物：
  描述：

  (1-ethoxycarbonyl-5-methyl-2-oxo-cyclohexyl)-acetic acid ethyl ester 在 盐酸 作用下， 生成 4-Methylcyclohexan-1-on-2-essigsaeure
  参考文献：
  名称：

  Monoclonal anti-EGFreceptor antibody (ior-R3) pharmacokinetic study in tumor bearing nude mice: Role of the receptor-mediated endocytosis on drug clearance

  摘要：

  With the purpose of describing the MAb ior-R3's kinetic behavior in disease state, this paper is focused on the study of this response using a human cancer (lung carcinoma cell line, H 125) bearing nude mice animal model. This MAb was administered by a single 16 mg/Kg intravenous bolus dose and the blood samples were collected at several times ranging from 0 to 72 hours for serum drug quantification. The experimental data set was best fitted using a classical two- compartment mammilary pharmacokinetic (PK) model and the corresponding PK parameters were determined. Comparativel, the analysis of the more relevant physiologically-based PK parameters showed a significant enhancing of clearance as compound with the earlier reported study on healthy mice, increasing from 0.09 to 0.19 mL/h (p<0.01). However, the corresponding distribution volumes don't seem to be altered by the tumor xenograft. We conclude that all of these evidences suggest a possible mechanism of receptor- mediated endocytosis (RME) as a major cause of this increased drug clearance which also contributed to the faster decrease of the drug disposition.

  DOI：

  10.1007/bf03190423

文献信息

• BAJAJ H. S.; DESAI R. D.; SAHARIA G. S., J. INDIAN CHEM. SOC. <JICS-AH>, 1975, 52, NO 10, 962-965
  作者：BAJAJ H. S.、 DESAI R. D.、 SAHARIA G. S.

  DOI：——

  日期：——
• Monoclonal anti-EGFreceptor antibody (ior-R3) pharmacokinetic study in tumor bearing nude mice: Role of the receptor-mediated endocytosis on drug clearance
  作者：J. Duconge、E. Fernández-Sánchez、A. Macías、R. Castillo、I. Garcia、I. Beausoleil、J. F. Amador、J. Matheu

  DOI：10.1007/bf03190423

  日期：2002.6

  With the purpose of describing the MAb ior-R3's kinetic behavior in disease state, this paper is focused on the study of this response using a human cancer (lung carcinoma cell line, H 125) bearing nude mice animal model. This MAb was administered by a single 16 mg/Kg intravenous bolus dose and the blood samples were collected at several times ranging from 0 to 72 hours for serum drug quantification. The experimental data set was best fitted using a classical two- compartment mammilary pharmacokinetic (PK) model and the corresponding PK parameters were determined. Comparativel, the analysis of the more relevant physiologically-based PK parameters showed a significant enhancing of clearance as compound with the earlier reported study on healthy mice, increasing from 0.09 to 0.19 mL/h (p<0.01). However, the corresponding distribution volumes don't seem to be altered by the tumor xenograft. We conclude that all of these evidences suggest a possible mechanism of receptor- mediated endocytosis (RME) as a major cause of this increased drug clearance which also contributed to the faster decrease of the drug disposition.