(S)-4'-((6-((1-(3-fluoro-4-methylphenyl)ethyl)carbamoyl)-3,4-dihydroquinoline-1(2H)-yl)methyl)-[1,1'-biphenyl]-2-caboxylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: (S)-4'-((6-((1-(3-fluoro-4-methylphenyl)ethyl)carbamoyl)-3,4-dihydroquinoline-1(2H)-yl)methyl)-[1,1'-biphenyl]-2-caboxylic acid
• 英文别名: 2-[4-[[6-[[(1S)-1-(3-fluoro-4-methylphenyl)ethyl]carbamoyl]-3,4-dihydro-2H-quinolin-1-yl]methyl]phenyl]benzoic acid
• 化学式: C₃₃H₃₁FN₂O₃
• 分子量: 522.619
• InChiKey: LGMQIGSHACIOFZ-QFIPXVFZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  39
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  69.6
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• COMPOUND BINDING TO PPARG BUT NOT ACTING AS PROMOTER AND PHARMACEUTICAL COMPOSITION FOR TREATING PPARG-RELATED DISEASES CONTAINING SAME AS ACTIVE INGREDIENT
  申请人：Hyundai Pharm Co., Ltd.

  公开号：US20160355483A1

  公开（公告）日：2016-12-08

  The present invention relates to a compound inhibiting CDK5-mediated PPARG phosphorylation and a pharmaceutical composition for treating PPARG-related diseases containing the same as an active ingredient. A compound represented by formula 1 or an optical isomer thereof according to the present invention that binds to PPARG at a high affinity level, but does not act as an agonist, thereby inducing no gene transcription; blocks CDK5, which is a cause of PPARG phosphorylation, thereby causing no side effects of existing anti-diabetic drugs; can be formulated into drugs due to improved pharmacological properties thereof; and can be favorably used as a pharmaceutical composition for treating PPARG-related diseases due to favorable treatment effects on PPARG-related diseases.

  本发明涉及一种抑制CDK5介导的PPARG磷酸化的化合物，以及含有该化合物作为活性成分的治疗PPARG相关疾病的药物组合物。根据本发明的化合物代表的公式1或其光学异构体结合到PPARG的亲和力高，但不起作为激动剂的作用，因此不会诱导基因转录；阻断CDK5，这是PPARG磷酸化的原因，从而不会引起现有抗糖尿病药物的副作用；由于其改进的药理特性，可以制成药物；由于对PPARG相关疾病的治疗效果良好，可以优选用作治疗PPARG相关疾病的药物组合物。