ethyl 2-(4,6-dichloroindolin-2-yl)acetate | 1494677-52-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: ethyl 2-(4,6-dichloroindolin-2-yl)acetate
• 英文别名: ethyl 2-(4,6-dichloro-2,3-dihydro-1H-indol-2-yl)acetate
• CAS: 1494677-52-9
• 化学式: C₁₂H₁₃Cl₂NO₂
• 分子量: 274.147
• InChiKey: MDUUOKXBCGLWIX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2,4-二氯-6-硝基苯胺 在 tin(II) chloride dihdyrate 、 sodium nitrite 作用下， 以 四氢呋喃 、 二氯甲烷 、 水 、 丙酮 为溶剂， 反应 7.0h， 生成 ethyl 2-(4,6-dichloroindolin-2-yl)acetate
  参考文献：
  名称：

  Facile Synthesis of Indolines by a Tandem Nitro-reduction Aza Michael Addition Reaction

  摘要：

  A diverse array of substrates are conveniently prepared by coupling diazonium salts to ethyl vinyl ether and subjecting the resultant aldehyde intermediate to a Wittig reaction to provide alpha,beta-unsaturated esters with only one purification step. The cyclisation of 4-aryl-but-2-enoates is carried out in the presence of stoichiometric amounts of SnCl2 center dot 2H(2)O and thus this one-pot strategy also permitted the expeditious synthesis of indolines in good yield.

  DOI：

  10.3987/com-13-12789

文献信息

• Facile Synthesis of Indolines by a Tandem Nitro-reduction Aza Michael Addition Reaction
  作者：Jason Guy Taylor、Wellington Martins Ventura、Luiz Guilherme Souza de Assis

  DOI：10.3987/com-13-12789

  日期：——

  A diverse array of substrates are conveniently prepared by coupling diazonium salts to ethyl vinyl ether and subjecting the resultant aldehyde intermediate to a Wittig reaction to provide alpha,beta-unsaturated esters with only one purification step. The cyclisation of 4-aryl-but-2-enoates is carried out in the presence of stoichiometric amounts of SnCl2 center dot 2H(2)O and thus this one-pot strategy also permitted the expeditious synthesis of indolines in good yield.