N-{1-[(2-methoxyphenyl)carbonyl]-2-methyl-1,2,3,4-tetrahydroquinolin-4-yl}-2-phenoxy-N-phenylacetamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N-{1-[(2-methoxyphenyl)carbonyl]-2-methyl-1,2,3,4-tetrahydroquinolin-4-yl}-2-phenoxy-N-phenylacetamide
• 英文别名: N-[1-(2-methoxybenzoyl)-2-methyl-3,4-dihydro-2H-quinolin-4-yl]-2-phenoxy-N-phenylacetamide
• 化学式: C₃₂H₃₀N₂O₄
• mdl: MFCD02127744
• 分子量: 506.6
• InChiKey: GQSKJONRMVNOFF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  38
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  59.1
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Asthma and allergic inflammation modulators
  申请人：Inman D. Wayne

  公开号：US20050038070A1

  公开（公告）日：2005-02-17

  Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment of inflammatory and immune-related diseases and conditions. In particular, the invention provides compounds which modulate the function and/or expression of proteins involved in atopic diseases, inflammatory conditions and cancer. The subject compounds are tetrahydroquinoline derivatives.

  本发明提供了可用于治疗炎症和免疫相关疾病和病症的化合物、药物组合物和方法。特别是，本发明提供了调节特应性疾病、炎症和癌症相关蛋白质功能和/或表达的化合物。所述化合物为四氢喹啉衍生物。
• [EN] ASTHMA AND ALLERGIC INFLAMMATION MODULATORS<br/>[FR] MODULATEURS D'ASTHME ET D'INFLAMMATIONS ALLERGIQUES
  申请人：TULARIK INC

  公开号：WO2005007094A2

  公开（公告）日：2005-01-27

  Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment of inflammatory and immune-related diseases and conditions. In particular, the invention provides compounds which modulate the function and/or expression of proteins involved in atopic diseases, inflammatory conditions and cancer. The subject compounds are tetrahydroquinoline derivatives.