N-[2-(benzo[c]acridin-7-ylamino)ethyl]-N-methylpropanimidamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N-[2-(benzo[c]acridin-7-ylamino)ethyl]-N-methylpropanimidamide
• 化学式: C₂₃H₂₄N₄
• 分子量: 356.5
• InChiKey: JDFUJLRWTVDHLH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  52
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Design, synthesis, and biological activity of platinum-benz[c]acridine hybrid agents and methods associated therewith
  申请人：WAKE FOREST UNIVERSITY

  公开号：US10023599B2

  公开（公告）日：2018-07-17

  The present invention relates to the compounds of formula I, pharmaceutically acceptable salts, and solvates thereof: wherein the various substituents are as defined herein. The compounds, solvates and salts thereof of Formula I are effective as anti-cancer compounds.

  本发明涉及式 I 的化合物、药学上可接受的盐及其溶液： 其中各种取代基如本文所定义。式 I 的化合物、其溶液和盐作为抗癌化合物是有效的。
• Design, Synthesis, and Biological Activity of Platinum-benz[c]acridine Hybrid Agents and Methods Associated Therewith
  申请人：WAKE FOREST UNIVERSITY

  公开号：US20170081351A1

  公开（公告）日：2017-03-23

  The present invention relates to the compounds of formula I, pharmaceutically acceptable salts, and solvates thereof: wherein the various substituents are as defined herein. The compounds, solvates and salts thereof of Formula I are effective as anti-cancer compounds.