ethyl N-[3-(morpholin-4-yl)propyl]carbamate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: ethyl N-[3-(morpholin-4-yl)propyl]carbamate
• 英文别名: ethyl N-(3-morpholin-4-ylpropyl)carbamate
• 化学式: C₁₀H₂₀N₂O₃
• mdl: MFCD03363528
• 分子量: 216.28
• InChiKey: XKTZOFSEXQWYHA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  50.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  ethyl N-[3-(morpholin-4-yl)propyl]carbamate 在 硝酸 、 caesium carbonate 、 sodium nitrite 作用下， 以 1,4-二氧六环 、 乙醚 、 水 为溶剂， 反应 12.0h， 生成 4-(3-phenylpropyl)morpholine
  参考文献：
  名称：

  10.1002/anie.202408432

  摘要：

  AbstractA strategy for transition metal‐free cross‐coupling of alkyl nitroso‐carbamates and boronic acids is reported. The N‐nitroso carbamates are easily prepared from the corresponding amine in two simple steps. This method allows for the synthesis of a wide variety of secondary boronates, benzylic boronates and formal Csp3−Csp2 cross‐coupling products under operationally simple conditions. Functional group tolerance is also demonstrated and applied in the modification of lysine to make non‐canonical amino acids.

  DOI：

  10.1002/anie.202408432
• 作为产物：
  描述：

  氯甲酸乙酯 、 N-(3-氨丙基)吗啉 在 三乙胺 、 硝酸 、 sodium nitrite 作用下， 以 二氯甲烷 为溶剂， 生成 ethyl N-[3-(morpholin-4-yl)propyl]carbamate
  参考文献：
  名称：

  10.1002/anie.202408432

  摘要：

  AbstractA strategy for transition metal‐free cross‐coupling of alkyl nitroso‐carbamates and boronic acids is reported. The N‐nitroso carbamates are easily prepared from the corresponding amine in two simple steps. This method allows for the synthesis of a wide variety of secondary boronates, benzylic boronates and formal Csp3−Csp2 cross‐coupling products under operationally simple conditions. Functional group tolerance is also demonstrated and applied in the modification of lysine to make non‐canonical amino acids.

  DOI：

  10.1002/anie.202408432

文献信息

• mTORC modulators and uses thereof
  申请人：Aeovian Pharmaceuticals, Inc.

  公开号：US11021492B2

  公开（公告）日：2021-06-01

  Novel rapamycin analogs and uses thereof are disclosed herein. The rapamycin analogs of the present disclosure show increased mTORC1 specificity and lowered mTORC2 specificity relative to rapamycin.

  本文公开了新型雷帕霉素类似物及其用途。 与雷帕霉素相比，本公开的雷帕霉素类似物显示出更高的 mTORC1 特异性和更低的 mTORC2 特异性。
• MTORC MODULATORS AND USES THEREOF
  申请人：Aeovian Pharmaceuticals, Inc.

  公开号：US20210002300A1

  公开（公告）日：2021-01-07

  Novel rapamycin analogs and uses thereof are disclosed herein. The rapamycin analogs of the present disclosure show increased mTORC1 specificity and lowered mTORC2 specificity relative to rapamycin.
• [EN] MTORC1 MODULATORS AND USES THEREOF<br/>[FR] MODULATEURS DE MTORC1 ET LEURS UTILISATIONS
  申请人：AEOVIAN PHARMACEUTICALS INC

  公开号：WO2021195599A1

  公开（公告）日：2021-09-30

  The disclosure provides compounds and salts that show high selectivity and inhibitory activity for mTORC1 and uses thereof for the treatment of disease.