9-chloro-4,5-dihydro-2-(2-thienyl)-6H-imidazo[4,5,1-ij]quinolin-6-one | 134602-21-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 9-chloro-4,5-dihydro-2-(2-thienyl)-6H-imidazo[4,5,1-ij]quinolin-6-one
• 英文别名: 5-Chloro-2-thiophen-2-yl-1,3-diazatricyclo[6.3.1.04,12]dodeca-2,4,6,8(12)-tetraen-9-one
• CAS: 134602-21-4
• 化学式: C₁₄H₉ClN₂OS
• 分子量: 288.757
• InChiKey: GAAAPWSRSYSQEY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  63.1
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• 4,5-Dihydro-6H-imidazo[4,5,1-ij]quinolin-6-one-6-oxime-O-sulfonic acid derivatives
  申请人：MOCHIDA PHARMACEUTICAL CO., LTD.

  公开号：EP0405442A1

  公开（公告）日：1991-01-02

  The present invention relates to novel 4,5-dihydro-6H-imidazo[4,5,1-ij]quinolin-6-one-6-oxime-0-sulfonic acid compounds, processes for producing said compounds, intermediate compounds, i.e. novel 4,5-dihydro-6H-imidazo[4,5,1-ij]quinolin-6-one compounds and 4,5-dihydro-6H-imidazo[4,5,1-ij]quinolin-6-one-6-oxime compounds in the synthesis of said compounds, processes for producing said intermediate compounds, and pharmaceutical or veterinary compositions containing said compounds. The present invention is based on the selection of the substituents of 4,5-dihydro-6H-imidazo[4,5,1-ij]-quinolin-6-one-6-oxime-O-sulfonic acid compounds at 2-position, namely 2-(2-penten-3-yl)-, 2-cyclohexyl-, 2-naphthyl-, 2-thienyl-, etc. The compounds of the present invention containing these substituents have potent- hypotensive, antioedematous and diuretic effects as well as an activity of removing ascites. The compounds of the present invention are extremely useful for treatment of diseases and disorders mentioned above.

  本发明涉及新型 4,5-二氢-6H-咪唑并[4,5,1-ij]喹啉-6-酮-6-肟-0-磺酸化合物、生产上述化合物的工艺、中间化合物，即新型 4,5-二氢-6H-咪唑并[4,5,1-ij]喹啉-6-酮化合物和合成所述化合物的 4,5-二氢-6H-咪唑并[4,5,1-ij]喹啉-6-酮-6-肟化合物，生产所述中间化合物的工艺，以及含有所述化合物的药物或兽药组合物。 本发明基于对 4,5-二氢-6H-咪唑并[4,5,1-ij]-喹啉-6-酮-6-肟-O-磺酸化合物 2-位取代基的选择，即 2-(2-戊烯-3-基)-、2-环己基-、2-萘基-、2-噻吩基-等。 含有这些取代基的本发明化合物具有强效降血压、消肿和利尿作用，并具有去除腹水的活性。本发明的化合物对治疗上述疾病和失调非常有用。
• US5151431A
  申请人：——

  公开号：US5151431A

  公开（公告）日：1992-09-29