9-(4-nitrophenyl)-2-(pyrrolidine-1-yl)-5,6,7,8-tetrahydrothiazolo [4,5-b]quinoline

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 9-(4-nitrophenyl)-2-(pyrrolidine-1-yl)-5,6,7,8-tetrahydrothiazolo [4,5-b]quinoline
• 英文别名: 9-(4-Nitrophenyl)-2-pyrrolidin-1-yl-5,6,7,8-tetrahydro-[1,3]thiazolo[4,5-b]quinoline；9-(4-nitrophenyl)-2-pyrrolidin-1-yl-5,6,7,8-tetrahydro-[1,3]thiazolo[4,5-b]quinoline
• 化学式: C₂₀H₂₀N₄O₂S
• 分子量: 380.47
• InChiKey: CYPGSHIGYVLCAE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  27
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  103
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• 2,5,6,7-tetrasubstituted Thiazolo[4,5-b]pyridine Derivatives and Use Thereof
  申请人：KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

  公开号：US20150307516A1

  公开（公告）日：2015-10-29

  Provided are a pharmaceutical composition containing a 2,5,6,7-tetrasubstituted thiazolo[4,5-b]pyridine derivative represented by Formula 1 as an active ingredient and a use thereof effective on a vascular inflammation-related infectious disease triggered by activity of HMGB1 protein. As investigating an anti-sepsis effect through a CLP-induced sepsis animal test that a sepsis survival rate is increased, it is identified that the pharmaceutical composition contains the 2,5,6,7-tetrasubstituted thiazolo[4,5-b]pyridine derivative or a pharmaceutically available salt thereof as an active ingredient to be used as a therapeutic agent for a vascular inflammatory disease and infectious disease including sepsis triggered by activity of HMGB1 protein.

  提供了一种药物组合物，其含有一种由化学式1表示的2,5,6,7-四取代噻唑并[4,5-b]吡啶衍生物作为活性成分，以及其在由HMGB1蛋白活性引发的血管炎症相关感染性疾病上的有效用途。通过对CLP诱导的败血症动物试验研究抗败血症效果，发现药物组合物含有2,5,6,7-四取代噻唑并[4,5-b]吡啶衍生物或其药用可用盐作为活性成分，可用作治疗血管炎症性疾病和由HMGB1蛋白活性引发的感染性疾病，包括败血症的治疗剂。
• US9932355B2
  申请人：——

  公开号：US9932355B2

  公开（公告）日：2018-04-03