3-Amino-1-(4-ethoxy-phenyl)-1,5-dihydro-pyrido[3,2-b]indol-2-one | 696647-49-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 3-Amino-1-(4-ethoxy-phenyl)-1,5-dihydro-pyrido[3,2-b]indol-2-one
• 英文别名: 3-amino-1-(4-ethoxyphenyl)-1,5-dihydro-2H-pyrido[3,2-b]indol-2-one；3-amino-1-(4-ethoxyphenyl)-5H-pyrido[3,2-b]indol-2-one
• CAS: 696647-49-1
• 化学式: C₁₉H₁₇N₃O₂
• mdl: MFCD05258728
• 分子量: 319.363
• InChiKey: AWNKXPVGTYZJGB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  71.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-Amino-1-(4-ethoxy-phenyl)-1,5-dihydro-pyrido[3,2-b]indol-2-one 在 联苯 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 3.5h， 生成 6-(4-Ethoxy-phenyl)-1,5-dioxo-4,5,6,11-tetrahydro-1H-4,6,11-triaza-benzo[a]fluorene-2-carboxylic acid ethyl ester
  参考文献：
  名称：

  Synthesis of derivatives of a new heterocyclic system, indolo[2,3-f][1,7]naphthyridine

  摘要：

  3-(N'-Aryl-N'-cliloroacetyl)amino-2-formyliildoles were converted into 3-amino-1-aryl2-oxo-1,2-dihvdropyrido[3,2-b]indoles, which were used to synthesize derivatives of a new heterocyclic system, namely, indolo [2.3-f][1,7] naphthyridine. The structures of the resulting Compounds were proved by IR and H-1 NMR spectroscopy and mass spectrometry.

  DOI：

  10.1023/b:rucb.0000011871.28637.78
• 作为产物：
  描述：

  3-[N-chloroacetyl-N-(4-ethoxyphenyl)amino]-2-formylindole 在 苄胺 作用下， 以 甲醇 为溶剂， 反应 3.0h， 生成 3-Amino-1-(4-ethoxy-phenyl)-1,5-dihydro-pyrido[3,2-b]indol-2-one
  参考文献：
  名称：

  Synthesis of derivatives of a new heterocyclic system, indolo[2,3-f][1,7]naphthyridine

  摘要：

  3-(N'-Aryl-N'-cliloroacetyl)amino-2-formyliildoles were converted into 3-amino-1-aryl2-oxo-1,2-dihvdropyrido[3,2-b]indoles, which were used to synthesize derivatives of a new heterocyclic system, namely, indolo [2.3-f][1,7] naphthyridine. The structures of the resulting Compounds were proved by IR and H-1 NMR spectroscopy and mass spectrometry.

  DOI：

  10.1023/b:rucb.0000011871.28637.78

文献信息

• Synthesis of derivatives of a new heterocyclic system, indolo[2,3-f][1,7]naphthyridine
  作者：N. A. Rastorgueva、S. Yu. Ryabova、E. A. Lisitsa、L. M. Alekseeva、V. G. Granik

  DOI：10.1023/b:rucb.0000011871.28637.78

  日期：2003.10

  3-(N'-Aryl-N'-cliloroacetyl)amino-2-formyliildoles were converted into 3-amino-1-aryl2-oxo-1,2-dihvdropyrido[3,2-b]indoles, which were used to synthesize derivatives of a new heterocyclic system, namely, indolo [2.3-f][1,7] naphthyridine. The structures of the resulting Compounds were proved by IR and H-1 NMR spectroscopy and mass spectrometry.