Arg-Ile-Lys-Ile-Gly-Leu-Phe-NH2 | 1160810-24-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Arg-Ile-Lys-Ile-Gly-Leu-Phe-NH2
• 英文别名: PMTX-(1-7)；P-7；H-Arg-Ile-Lys-Ile-Gly-Leu-Phe-NH2；(2S)-6-amino-2-[[(2S,3S)-2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-3-methylpentanoyl]amino]-N-[(2S,3S)-1-[[2-[[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-methyl-1-oxopentan-2-yl]hexanamide
• CAS: 1160810-24-1
• 化学式: C₄₁H₇₂N₁₂O₇
• 分子量: 845.099
• InChiKey: ZETLDQXIEUWUJE-LQPOEIMQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  60
• 可旋转键数：
  29
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.66
• 拓扑面积：
  334
• 氢给体数：
  11
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  Fmoc-Phe-OH 、 Fmoc-甘氨酸 、 Fmoc-L-亮氨酸 、 Fmoc-L-异亮氨酸 、 N-alpha-芴甲氧羰基-N-epsilon-叔丁氧羰基-L-赖氨酸 、 Fmoc-Pbf-L-精氨酸 生成 Arg-Ile-Lys-Ile-Gly-Leu-Phe-NH2
  参考文献：
  名称：

  A Synthetic Approach to Develop Peptide Inhibitors Selective for Brain-Type Sodium Channels on the Basis of Pompilidotoxin Structure

  摘要：

  To develop inhibitors that are selective for brain-type sodium channels, several peptides were synthesized on the basis of pompilidotoxin structure. A peptide having N-terminal 7 amino acids and its homologs in which Phe(7) is substituted into more hydrophobic amino acids, selectively inhibit sodium current of brain-type sodium channels.

  DOI：

  10.3987/com-08-s(d)67

文献信息

• A Synthetic Approach to Develop Peptide Inhibitors Selective for Brain-Type Sodium Channels on the Basis of Pompilidotoxin Structure
  作者：Hitoshi Nakayama、Sawana Yokote、Ritsuko Setoguchi、Eisuke Shimizu、Kohichi Kawahara、Akihiko Kuniyasu、Tetsuya Shirasaki、Kazuo Takahama、Nobufumi Kawai、Kaoru Yamaoka、Eiji Kinoshita

  DOI：10.3987/com-08-s(d)67

  日期：——

  To develop inhibitors that are selective for brain-type sodium channels, several peptides were synthesized on the basis of pompilidotoxin structure. A peptide having N-terminal 7 amino acids and its homologs in which Phe(7) is substituted into more hydrophobic amino acids, selectively inhibit sodium current of brain-type sodium channels.