2-(4-Aminophenyl)-6-bromoquinoline-4-carbohydrazide | 5350-87-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-(4-Aminophenyl)-6-bromoquinoline-4-carbohydrazide
• CAS: 5350-87-8
• 化学式: C₁₆H₁₃BrN₄O
• 分子量: 357.2
• InChiKey: ADOVMKXWNWCKIX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  94
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• QUINOLINE DERIVATIVE AS DIAGNOSTIC PROBE FOR DISEASE WITH TAU PROTEIN ACCUMULATION
  申请人：BF Research Institute, Inc.

  公开号：EP1574500A1

  公开（公告）日：2005-09-14

  The present invention provides compounds, or salts or solvates thereof, which can be used as probes for the imaging diagnosis of diseases in which tau protein accumulates, and compositions and kits comprising such compounds, or salts or solvates thereof. The present invention also provides a method for staining neurofibrillary tangles in brain samples, and a pharmaceutical composition for the treatment and/or prophylaxis of a disease in which β-sheet structure is the cause or possible cause.

  本发明提供了可用作tau蛋白聚集疾病成像诊断探针的化合物或其盐或溶物，以及包含此类化合物或其盐或溶物的组合物和试剂盒。本发明还提供了一种染色脑样本中神经纤维缠结的方法，以及一种用于治疗和/或预防以β片状结构为病因或可能病因的疾病的药物组合物。
• Quinoline derivative as diagnostic probe for disease with tau protein accumulation
  申请人：Kudo Yukitsuka

  公开号：US20050009865A1

  公开（公告）日：2005-01-13

  The present invention provides compounds, or salts or solvates thereof, which can be used as probes for the imaging diagnosis of diseases in which tau protein accumulates, and compositions and kits comprising such compounds, or salts or solvates thereof. The present invention also provides a method for staining neurofibrillary tangles in brain samples, and a pharmaceutical composition for the treatment and/or prophylaxis of a disease in which β-sheet structure is the cause or possible cause.

  本发明提供了可用作tau蛋白聚集疾病成像诊断探针的化合物或其盐或溶物，以及包含此类化合物或其盐或溶物的组合物和试剂盒。本发明还提供了一种染色脑样本中神经纤维缠结的方法，以及一种用于治疗和/或预防以β片状结构为病因或可能病因的疾病的药物组合物。
• HETEROCYCLIC COMPOUNDS AS IMAGING PROBES OF TAU PATHOLOGY
  申请人：GE Healthcare UK Limited

  公开号：EP2640703A1

  公开（公告）日：2013-09-25
• US7118730B2
  申请人：——

  公开号：US7118730B2

  公开（公告）日：2006-10-10
• US9040021B2
  申请人：——

  公开号：US9040021B2

  公开（公告）日：2015-05-26