2-(4-nitro-phenyl)-4,5-di-p-tolyl-1H-imidazole | 169155-33-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-(4-nitro-phenyl)-4,5-di-p-tolyl-1H-imidazole
• 英文别名: 4,5-bis(4-methylphenyl)-2-(4-nitrophenyl)-1H-imidazole
• CAS: 169155-33-3
• 化学式: C₂₃H₁₉N₃O₂
• mdl: MFCD00351170
• 分子量: 369.423
• InChiKey: NABGIIGYLCLPNZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  28
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  74.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(4-nitro-phenyl)-4,5-di-p-tolyl-1H-imidazole 、 碘甲烷 在 potassium carbonate 作用下， 生成 1-Methyl-2-(4-nitro-phenyl)-4,5-di-p-tolyl-1H-imidazole
  参考文献：
  名称：

  New class of imidazoles incorporated with thiophenevinyl conjugation pathway for robust nonlinear optical chromophores

  摘要：

  A new series of thermally stable heterocyclic imidazole-based nonlinear optical chromophores has been developed. These chromophores possess a thiophene based stilbene conjugation pathway with a nitro acceptor group attached to the phenyl end. This feature leads to robust chromophores with high thermal stability and enhanced molecular nonlinearity. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(00)02143-2
• 作为产物：
  描述：

  4,4'-二甲基联苯甲酰 、 对硝基苯甲醛 在 乙酸铵 、 1-butylimidazolium tetrafluoroborate 作用下， 反应 1.17h， 以87%的产率得到2-(4-nitro-phenyl)-4,5-di-p-tolyl-1H-imidazole
  参考文献：
  名称：

  室温离子液体促进了由芳基醛和1,2-二酮或α-羟基酮快速合成2,4,5-三芳基咪唑

  摘要：

  描述了一种在室温离子液体中改进，快速的一锅法合成2,4,5-三芳基咪唑，不需要任何添加的催化剂。筛选了基于1-正丁基和1,3-二正丁基咪唑鎓盐的不同离子液体，其在酸度和极性方面的功效与产率和反应时间相关。一锅法可在较短的反应时间内获得出色的分离收率，其特点是后处理步骤简单，可有效回收和循环用作助催化剂的离子液体。

  DOI：

  10.1016/j.tet.2005.01.116

文献信息

• New class of imidazoles incorporated with thiophenevinyl conjugation pathway for robust nonlinear optical chromophores
  作者：Javier Santos、Eric A Mintz、Oliver Zehnder、Christian Bosshard、Xiu R Bu、Peter Günter

  DOI：10.1016/s0040-4039(00)02143-2

  日期：2001.1

  A new series of thermally stable heterocyclic imidazole-based nonlinear optical chromophores has been developed. These chromophores possess a thiophene based stilbene conjugation pathway with a nitro acceptor group attached to the phenyl end. This feature leads to robust chromophores with high thermal stability and enhanced molecular nonlinearity. (C) 2001 Elsevier Science Ltd. All rights reserved.
• Room temperature ionic liquid promoted improved and rapid synthesis of 2,4,5-triaryl imidazoles from aryl aldehydes and 1,2-diketones or α-hydroxyketone
  作者：Shapi A. Siddiqui、Umesh C. Narkhede、Sanjay S. Palimkar、Thomas Daniel、Rajgopal J. Lahoti、Kumar V. Srinivasan

  DOI：10.1016/j.tet.2005.01.116

  日期：2005.4

  An improved and rapid one-pot synthesis of 2,4,5-triaryl imidazoles in a room temperature ionic liquid is described, which does not need any added catalyst. Different ionic liquids based on 1-n-butyl and 1,3-di-n-butyl imidazolium salts were screened and their efficacy in terms of acidity and polarity have been correlated with yields and reaction period. The one-pot methodology resulting in excellent

  描述了一种在室温离子液体中改进，快速的一锅法合成2,4,5-三芳基咪唑，不需要任何添加的催化剂。筛选了基于1-正丁基和1,3-二正丁基咪唑鎓盐的不同离子液体，其在酸度和极性方面的功效与产率和反应时间相关。一锅法可在较短的反应时间内获得出色的分离收率，其特点是后处理步骤简单，可有效回收和循环用作助催化剂的离子液体。