5-methoxy-5H-pyrido[4,3-b]indole | 1313869-93-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 5-methoxy-5H-pyrido[4,3-b]indole
• 英文别名: 9-methoxy-5H-pyrido[4,3-b]indole
• CAS: 1313869-93-0
• 化学式: C₁₂H₁₀N₂O
• 分子量: 198.224
• InChiKey: OJFXGXVANNUTQC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  37.9
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3-chloro-N-(3-methoxy)phenylpyridin-4-amine 在 potassium tert-butylate 、 氨 作用下， 反应 1.0h， 生成 5-methoxy-5H-pyrido[4,3-b]indole 、 7-methoxy-5H-pyrido[4,3-b]indole
  参考文献：
  名称：

  Synthesis of Carbolines by Photostimulated Cyclization of Anilinohalopyridines

  摘要：

  A general synthetic route to prepare all four carboline regioisomers by photo stimulated cyclization of anilinohalopyridines is described. The methodology affords various substituted carbolines in good to excellent yields. In the case of alpha-carbolines, the S(RN)1 methodology complements previously reported palladium-catalyzed cyclization approaches.

  DOI：

  10.1021/jo200923n

文献信息

• Synthesis of Carbolines by Photostimulated Cyclization of Anilinohalopyridines
  作者：Joydev K. Laha、Silvia M. Barolo、Roberto A. Rossi、Gregory D. Cuny

  DOI：10.1021/jo200923n

  日期：2011.8.5

  A general synthetic route to prepare all four carboline regioisomers by photo stimulated cyclization of anilinohalopyridines is described. The methodology affords various substituted carbolines in good to excellent yields. In the case of alpha-carbolines, the S(RN)1 methodology complements previously reported palladium-catalyzed cyclization approaches.