3-chloro-N-(3-methoxy)phenylpyridin-4-amine | 1313869-89-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 3-chloro-N-(3-methoxy)phenylpyridin-4-amine
• 英文别名: 3-chloro-N-(3-methoxyphenyl)pyridin-4-amine
• CAS: 1313869-89-4
• 化学式: C₁₂H₁₁ClN₂O
• 分子量: 234.685
• InChiKey: SBZYHQSCZVSMDU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  34.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-chloro-N-(3-methoxy)phenylpyridin-4-amine 在 potassium tert-butylate 、 氨 作用下， 反应 1.0h， 生成 5-methoxy-5H-pyrido[4,3-b]indole 、 7-methoxy-5H-pyrido[4,3-b]indole
  参考文献：
  名称：

  Synthesis of Carbolines by Photostimulated Cyclization of Anilinohalopyridines

  摘要：

  A general synthetic route to prepare all four carboline regioisomers by photo stimulated cyclization of anilinohalopyridines is described. The methodology affords various substituted carbolines in good to excellent yields. In the case of alpha-carbolines, the S(RN)1 methodology complements previously reported palladium-catalyzed cyclization approaches.

  DOI：

  10.1021/jo200923n
• 作为产物：
  描述：

  3,4-二氯吡啶 、 间氨基苯甲醚 在 palladium diacetate 、 三苯基膦 作用下， 以 甲苯 为溶剂， 以45%的产率得到3-chloro-N-(3-methoxy)phenylpyridin-4-amine
  参考文献：
  名称：

  Synthesis of Carbolines by Photostimulated Cyclization of Anilinohalopyridines

  摘要：

  A general synthetic route to prepare all four carboline regioisomers by photo stimulated cyclization of anilinohalopyridines is described. The methodology affords various substituted carbolines in good to excellent yields. In the case of alpha-carbolines, the S(RN)1 methodology complements previously reported palladium-catalyzed cyclization approaches.

  DOI：

  10.1021/jo200923n

文献信息

• Synthesis of Carbolines by Photostimulated Cyclization of Anilinohalopyridines
  作者：Joydev K. Laha、Silvia M. Barolo、Roberto A. Rossi、Gregory D. Cuny

  DOI：10.1021/jo200923n

  日期：2011.8.5

  A general synthetic route to prepare all four carboline regioisomers by photo stimulated cyclization of anilinohalopyridines is described. The methodology affords various substituted carbolines in good to excellent yields. In the case of alpha-carbolines, the S(RN)1 methodology complements previously reported palladium-catalyzed cyclization approaches.