4,5-bis(4-methoxyphenyl)-2-(4-nitrophenyl)-1H-imidazole | 97717-40-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4,5-bis(4-methoxyphenyl)-2-(4-nitrophenyl)-1H-imidazole
• 英文别名: 2-(4-Nitrophenyl)-4,5-bis(4-methoxyphenyl)imidazole
• CAS: 97717-40-3
• 化学式: C₂₃H₁₉N₃O₄
• 分子量: 401.422
• InChiKey: IXUTWWDHBGYXJO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  30
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  93
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  正溴丁烷 、 4,5-bis(4-methoxyphenyl)-2-(4-nitrophenyl)-1H-imidazole 在 sodium hydroxide 、 C₆H₅CH=C[CH₂N⁽¹⁺⁾Et₃Br^(1-)]2 作用下， 以 二氯甲烷 为溶剂， 反应 5.0h， 生成 1-butyl-2-(4'-nitrophenyl)-4,5-bis(p-methoxyphenyl) imidazole
  参考文献：
  名称：

  在 PTC 条件下使用新的相转移试剂对 2,4,5-三苯基咪唑衍生物进行 N-烷基化

  摘要：

  相转移催化 2,4,5-三苯基咪唑衍生物的 N-烷基化反应，使用一种新的相转移试剂，即 2-benzilidine-N,N,N,N',N',N'-hexaethyl propane-1,3 -二溴化二铵已被描述。所有 14 种化合物的结构均已通过光谱方法确定。

  DOI：

  10.1081/scc-100105320
• 作为产物：
  描述：

  4,5-bis(4-methoxyphenyl)-2-(4-nitrophenyl)imidazole hydrochloride 在 氢氧化钾 作用下， 以 水 为溶剂， 生成 4,5-bis(4-methoxyphenyl)-2-(4-nitrophenyl)-1H-imidazole
  参考文献：
  名称：

  Sakaino, Yoshiko; Takizawa, Toshiharu; Inouye, Yoshinobu, Journal of the Chemical Society. Perkin transactions II, 1986, p. 1623 - 1630

  摘要：

  DOI：

文献信息

• Facile fabrication of porous magnetic covalent organic frameworks as robust platform for multicomponent reaction
  作者：Najmedin Azizi、Fatemeh Heidarzadeh、Fezeh Farzaneh

  DOI：10.1002/aoc.6373

  日期：2021.11

  COF@Fe3O4 under hydrothermal conditions for the first time. The high surface area magnetic COF could exhibit superior catalytic activity for sustainable synthesis of trisubstituted and tetrasubstituted imidazoles and pyrroles in good to excellent yields in PEG as solvent under environmentally friendly, ambient conditions and making the overall process economical, efficient, and green. The retrievable

  为环境良性过程的广泛应用设计廉价而高效的纳米多孔磁性催化剂是一个极具吸引力且具有挑战性的化学研究领域。通过三聚氰胺与对苯二醛在3,4-二羟基苯甲醛包覆磁性Fe 3 O 4纳米颗粒COF@Fe 3 O 4表面缩合反应制备新型多孔磁性共价有机骨架第一次在热液条件下。高表面积磁性 COF 可以在环境友好、环境条件下以 PEG 作为溶剂的良好收率，对三取代和四取代咪唑和吡咯的可持续合成表现出优异的催化活性，并使整个过程经济、高效和绿色。PEG中的可回收催化剂是通用的，适用于广泛的底物范围和官能团兼容性。通过FTIR、XRD、EDX和SEM光谱对COF@Fe 3 O 4的结构和形貌进行了表征。COF@Fe 3 O 4 磁性催化剂通过外部磁铁回收并使用多个循环而没有显着的催化活性损失。
• FUEL FOR FUEL CELL, FUEL CELL AND APPLICATION THEREOF
  申请人：Kurita Water Industries Ltd.

  公开号：EP1705740A1

  公开（公告）日：2006-09-27

  A fuel cell fuel contains an organic fuel used as a fuel for a fuel cell. The organic fuel is in a form of a solid molecular compound, such as an inclusion compound. The molecular compound can be prepared by contact catalytic reaction of a compound for forming the molecular compound and the organic fuel, and allows a liquid organic fuel to be in a solid compound to store the organic fuel stably in a relatively lightweight form. The molecular compound easily releases the organic fuel by, for example, heating, and the organic fuel is supplied to the fuel electrode of a fuel cell. Thus, the handleability of the fuel cell fuel containing the organic fuel can be improved, and the problems of corrosion, freezing of the fuel, crossover, and so forth can be solved.

  燃料电池燃料包含一种用作燃料电池燃料的有机燃料。有机燃料以固体分子化合物的形式存在，例如包合物。该分子化合物可通过一种化合物的接触催化反应制备，该化合物用于形成分子化合物和有机燃料，可将液态有机燃料置于固体化合物中，从而以相对较轻的形式稳定地储存有机燃料。通过加热等方式，分子化合物很容易释放出有机燃料，然后将有机燃料供应给燃料电池的燃料电极。这样，含有有机燃料的燃料电池燃料的可操作性就能得到改善，腐蚀、燃料冻结、交叉等问题也能得到解决。
• New class of imidazoles incorporated with thiophenevinyl conjugation pathway for robust nonlinear optical chromophores
  作者：Javier Santos、Eric A Mintz、Oliver Zehnder、Christian Bosshard、Xiu R Bu、Peter Günter

  DOI：10.1016/s0040-4039(00)02143-2

  日期：2001.1

  A new series of thermally stable heterocyclic imidazole-based nonlinear optical chromophores has been developed. These chromophores possess a thiophene based stilbene conjugation pathway with a nitro acceptor group attached to the phenyl end. This feature leads to robust chromophores with high thermal stability and enhanced molecular nonlinearity. (C) 2001 Elsevier Science Ltd. All rights reserved.
• Selective Sequential Cross-Coupling Reactions on Imidazole towards Neurodazine and Analogues
  作者：Michael Schnürch、Marko Mihovilovic、Lisa-Maria Recnik、Mohammed Abd El Hameid、Maximilian Haider

  DOI：10.1055/s-0032-1316906

  日期：——

  Polysubstituted imidazoles represent a common structural motif in bioactive molecules. A modular and flexible strategy towards 2,4,5-triarylated imidazoles is reported applying a Suzuki-Miyaura cross-coupling protocol. Employing 1-protected 2,4,5-tribromoimidazole as starting material, both stepwise and one-pot protocols towards the title compounds are disclosed. The utility of the approach was demonstrated by synthesizing neurodazine, a biologically active molecule affecting neuronal cell differentiation.
• Novel Charge-Transfer Chromophores Featuring Imidazole as π-Linkage
  作者：Filip Bureš、Anjan Patel、Miroslav Ludwig、Jiří Kulhánek、Oldřich Pytela、Aleš Růžička

  DOI：10.3987/com-08-11609

  日期：——

  Overall 21 imidazole-based chromophores have been synthesized and fully characterized. The imidazole core was systematically substituted with donors (NMe(2) and OMe) and acceptors (NO(2) and CN groups) additionally separated from the imidazole by pi-spacers such as 1,4-phenylen, styryl or thiophen-2-yl in order to finely tune their intramolecular charge transition. The target chromophores were further investigated by UV/Vis spectroscopy as potentially NLO-active compounds.