2-tert-butoxy-1-(4-chlorophenyl)ethanone | 1157190-26-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-tert-butoxy-1-(4-chlorophenyl)ethanone
• 英文别名: 1-(4-Chlorophenyl)-2-[(2-methylpropan-2-yl)oxy]ethanone
• CAS: 1157190-26-5
• 化学式: C₁₂H₁₅ClO₂
• 分子量: 226.703
• InChiKey: SUSFXYBEAOFKGM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-tert-butoxy-1-(4-chlorophenyl)ethanone 在 磺酰氯 作用下， 生成
  参考文献：
  名称：

  Discovery and SAR of small molecule PAR1 antagonists

  摘要：

  High-throughput screening resulted in the identication of a small molecule inhibitor of PAR1. Optimisation of the initial hit led to the discovery of compounds 34 and 49, which displayed antithrombotic activity in an arteriovenous shunt model in the rat after iv administration. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.12.072
• 作为产物：
  描述：

  2-Tert-butoxy-1-(4-chlorophenyl)ethanol 在 pyridinium chlorochromate 作用下， 以 二氯甲烷 为溶剂， 以100%的产率得到2-tert-butoxy-1-(4-chlorophenyl)ethanone
  参考文献：
  名称：

  Discovery and SAR of small molecule PAR1 antagonists

  摘要：

  High-throughput screening resulted in the identication of a small molecule inhibitor of PAR1. Optimisation of the initial hit led to the discovery of compounds 34 and 49, which displayed antithrombotic activity in an arteriovenous shunt model in the rat after iv administration. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.12.072

文献信息

• Highly Selective Synthesis of 2-<i>tert</i>-Butoxy-1-Arylethanones via Copper(I)-Catalyzed Oxidation/<i>tert</i>-Butoxylation of Aryl Olefins with TBHP
  作者：Jiantao Zhang、Duoduo Xiao、Hua Tan、Weibing Liu

  DOI：10.1021/acs.joc.9b03156

  日期：2020.3.6

  A practical and environmentally friendly protocol for the selective oxidation of aryl olefins to arylethanone derivatives by using a Cu(I) catalyst and tert-butyl hydroperoxide (TBHP) has been developed. A series of 2-tert-butoxy-1-arylethanones were obtained in moderate to good yields under mild conditions with high selectivity. In this method, TBHP acts not only as an oxidant but also as the tert-butoxy

  已经开发了一种实用且环保的方案，该方案通过使用Cu（I）催化剂和叔丁基氢过氧化物（TBHP）将芳基烯烃选择性氧化为芳烃酮衍生物。在温和条件下以高选择性以中等至良好的收率获得了一系列2-叔丁氧基-1-芳酮。在这种方法中，TBHP不仅起氧化剂的作用，而且还起叔丁氧基和羰基氧源的作用。这使得一步氧化/叔丁氧基化成为可能。还从烯丙基底物合成了各种烯丙基过氧化物。