6-Methyl-4-phenyl-3,4-dihydro-carbostyril | 16560-21-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 6-Methyl-4-phenyl-3,4-dihydro-carbostyril
• 英文别名: 6-methyl-4-phenyl-3,4-dihydro-1H-quinolin-2-one
• CAS: 16560-21-7
• 化学式: C₁₆H₁₅NO
• 分子量: 237.301
• InChiKey: KZJWXEIBVWBYTO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  6-Methyl-4-phenyl-3,4-dihydro-carbostyril 、 三氯化铝 以93%的产率得到
  参考文献：
  名称：

  MANIMARAN T.; RAMAKRISHNAN V. T., INDIAN J. CHEM., 1979, B 18, NO 4, 324-330

  摘要：

  DOI：
• 作为产物：
  描述：

  N-(4-甲基苯基)-3-苯基丙烯酰胺 以85%的产率得到
  参考文献：
  名称：

  MANIMARAN T.; RAMAKRISHNAN V. T., INDIAN J. CHEM., 1979, B 18, NO 4, 324-330

  摘要：

  DOI：

文献信息

• Rhodium-Catalyzed Tandem Conjugate Addition−Mannich Cyclization Reaction: Straightforward Access to Fully Substituted Tetrahydroquinolines
  作者：So Won Youn、Ju-Hyun Song、Dai-Il Jung

  DOI：10.1021/jo800914c

  日期：2008.7.1

  A new Rh(I)-catalyzed tandem conjugate addition−Mannich cyclization reaction of imine-substituted electron-deficient alkenes with arylboronic acids has been developed to afford 2,3,4-trisubstituted 1,2,3,4-tetrahydroquinolines. This is the first example involving imine group as a secondary electrophile in Rh(I)-catalyzed tandem reactions.

  已开发出一种新的Rh（I）催化的串联共轭加成反应-亚胺取代的电子缺陷烯烃与芳基硼酸的曼尼希环化反应，得到2,3,4-三取代的1,2,3,4-四氢喹啉。这是第一个涉及亚胺基作为Rh（I）催化串联反应中的第二亲电子试剂的例子。
• PIPERAZINE-SUBSTITUTED BENZOTHIOPHENES FOR TREATMENT OF MENTAL DISORDERS
  申请人：YAMASHITA Hiroshi

  公开号：US20110152286A1

  公开（公告）日：2011-06-23

  The present invention provides a heterocyclic compound represented by the general formula (1): The compound of the present invention has a wide treatment spectrum for mental disorders including central nervous system disorders, no side effects and high safety.

  本发明提供了一个由通式（1）所代表的杂环化合物：该化合物具有广泛的治疗精神障碍的光谱，包括中枢神经系统障碍，无副作用且安全性高。
• Piperazine-substituted benzothiophenes for treatment of mental disorders
  申请人：Yamashita Hiroshi

  公开号：US20100179322A1

  公开（公告）日：2010-07-15

  The present invention provides a heterocyclic compound represented by the general formula (1): The compound of the present invention has a wide treatment spectrum for mental disorders including central nervous system disorders, no side effects and high safety.

  本发明提供了由通式（1）表示的杂环化合物：本发明的化合物具有广泛的治疗精神障碍的光谱，包括中枢神经系统障碍，没有副作用和高安全性。
• STRODS YA. A.; LIELBRIEDIS I. EH.; NEJLAND O. YA., D1-LATVRSR ZINATNU ASAD. VESTIS. KIM. SER., IZV. AN LATVSSR. CEP. XIM., 1+
  作者：STRODS YA. A.、 LIELBRIEDIS I. EH.、 NEJLAND O. YA.

  DOI：——

  日期：——
• Piperazine-Substituted Benzothiophenes For Treatment of Mental Disorders
  申请人：Otsuka Pharmaceutical Co., Ltd.

  公开号：US20170000786A1

  公开（公告）日：2017-01-05

  The present invention provides a heterocyclic compound represented by the general formula (1): The compound of the present invention has a wide treatment spectrum for mental disorders including central nervous system disorders, no side effects and high safety.