Yo-Pro-1(2+)

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: Yo-Pro-1(2+)
• 英文别名: trimethyl-[3-[4-[(Z)-(3-methyl-1,3-benzoxazol-2-ylidene)methyl]quinolin-1-ium-1-yl]propyl]azanium
• 化学式: C24H29N3O+2
• 分子量: 375.5
• InChiKey: DWBLAOWJYNNBQB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  16.4
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• VITAL FLUOROCHROME CONJUGATES AND METHODS OF USE
  申请人：Josephson Lee

  公开号：US20120121509A1

  公开（公告）日：2012-05-17

  The present invention provides compositions and methods based on vital fluorochrome conjugates that are useful for imaging dying and dead cells.

  本发明提供了基于活性荧光染料结合物的组合物和方法，用于成像死亡和死亡细胞。
• Utilisation de composés polycationiques en teinture des fibres kératiniques
  申请人：L'OREAL

  公开号：EP1609459A1

  公开（公告）日：2005-12-28

  La présente demande a pour objet l'utilisation à titre de colorant direct dans des compositions tinctoriales pour fibres kératiniques, en particulier les fibres kératiniques humaines telles que les cheveux, ou pour la fabrication de telles compositions, d'un composé polycationique particulier.

  本申请的目的是将一种特定的多阳离子化合物作为直接染料，用于角蛋白纤维，特别是人类角蛋白纤维（如头发）的染色组合物中，或用于制造此类组合物。
• Use of polycationic compounds for dyeing keratin fibres
  申请人：Lagrange Alain

  公开号：US20060162098A1

  公开（公告）日：2006-07-27

  Use of polycationic compounds for dyeing keratin fibres The present patent application relates to the use, as direct dye in compositions for dyeing keratin fibres, in particular human keratin fibres such as the hair, or for the manufacture of such compositions, of a particular azo compound.

  多阳离子化合物在角蛋白纤维染色中的应用 本专利申请涉及一种特定偶氮化合物作为直接染料在角蛋白纤维（特别是人类角蛋白纤维，如头发）染色组合物中的应用，或用于制造此类组合物。
• Sequence Specific Fluorescence for Peptide-Fluorochrome Interactions
  申请人：MedChem Imaging

  公开号：US20180120325A1

  公开（公告）日：2018-05-03

  A method of obtaining fluorochromes that bind to specific sites on proteins is presented. The method consists of synthesizing a peptide bearing a sequence from a parent protein and a second peptide of similar composition but with a scrambled sequence. Each peptide is then added to a test fluorochrome at similar concentrations, and a difference in fluorescence is obtained. A difference in fluorescence indicates a sequence dependent interaction between the peptide and fluorochrome. A large number of fluorochromes can be screened using the two peptides to find one binding in a sequence dependent fashion. This fluorochrome can then be tested for binding to the original full-length protein. The fluorochrome can then serve as scaffold in medicinal chemistry. The fluorochrome/peptide interaction and resulting fluorescence can be inhibited by non-fluorescent test compounds, which are compounds that bind to this peptide. Thus. the peptide/fluorochrome interaction can provide assays screening for therapeutic drugs binding to this site on the protein.
• US8486638B2
  申请人：——

  公开号：US8486638B2

  公开（公告）日：2013-07-16