NCI150432

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: NCI150432
• 英文别名: 2-Chlor-4-nitro-6-(2-hydroxyethylamino)-phenanthridin；2-(2-chloro-4-nitro-phenanthridin-6-ylamino)-ethanol；2-((2-Chloro-4-(hydroxy(oxido)amino)-6-phenanthridinyl)amino)ethanol；2-[(2-chloro-4-nitrophenanthridin-6-yl)amino]ethanol
• 化学式: C₁₅H₁₂ClN₃O₃
• 分子量: 317.732
• InChiKey: VSWCCNDGUZELDO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  91
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• ANTAGONISTS OF THE TOLL-LIKE RECEPTOR 1/2 COMPLEX
  申请人：THE REGENTS OF THE UNIVERSITY OF COLORADO, a body corporate

  公开号：US20150251987A1

  公开（公告）日：2015-09-10

  Provided are compounds, compositions and methods for treating Toll-like receptor 1/2 complex (TLRI/2) related inflammatory disorders. Small molecules, based on the benzotropolone scaffold, capable of influencing downstream signaling are disclosed as well as methods of making and modifying these molecules. Also provided are methods for treating a subject for a clinical condition associated with Toll-like receptor complex 1/2 activation, comprising administering to the subject an effective amount of a benzotropolone compound.

  提供了用于治疗Toll样受体1/2复合物（TLRI/2）相关炎症性疾病的化合物、组合物和方法。公开了基于苯并三环酮支架的小分子，能够影响下游信号传导，以及制备和修改这些分子的方法。还提供了用于治疗与Toll样受体复合物1/2激活相关的临床状况的方法，包括向受试者施用有效量的苯并三环酮化合物。
• COMPOUNDS FOR TREATING ABNORMAL CELLULAR PROLIFERATION
  申请人：Taiga Biotechnologies, Inc.

  公开号：EP2214670A2

  公开（公告）日：2010-08-11
• US9517993B2
  申请人：——

  公开号：US9517993B2

  公开（公告）日：2016-12-13
• [EN] COMPOUNDS FOR TREATING ABNORMAL CELLULAR PROLIFERATION<br/>[FR] COMPOSÉS POUR TRAITER UNE PROLIFÉRATION CELLULAIRE ANORMALE
  申请人：TAIGA BIOTECHNOLOGIES INC

  公开号：WO2009059304A2

  公开（公告）日：2009-05-07

  Provided herein are compounds, compositions and methods for treating disorders mediated by abnormal cellular proliferation and processes for identifying such compounds.